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3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine - 1st Edition - ISBN: 9780128005477, 9780128006641

3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine

1st Edition

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Authors: Lijie Grace Zhang John P Fisher Kam Leong
Hardcover ISBN: 9780128005477
eBook ISBN: 9780128006641
Imprint: Academic Press
Published Date: 6th January 2015
Page Count: 392
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3D Bioprinting and Nanotechnology in Tissue Engineering provides an in depth introduction to these two technologies and their industrial applications. Stem cells in tissue regeneration are covered, along with nanobiomaterials. Commercialization, legal and regulatory considerations are also discussed in order to help you translate nanotechnology and 3D printing-based products to the marketplace and the clinic. Dr. Zhang’s and Dr. Fishers’ team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application.

The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs, and this book provides an overview of these technologies and their integration. It shows how nanotechnology can increase the clinical efficiency of prosthesis or artificial tissues made by bioprinting or biofabrication. Students and professionals will receive a balanced assessment of relevant technology with theoretical foundation, while still learning about the newest printing techniques.

Key Features

  • Includes clinical applications, regulatory hurdles, and risk-benefit analysis of each technology.
  • This book will assist you in selecting the best materials and identifying the right parameters for printing, plus incorporate cells and biologically active agents into a printed structure
  • Learn the advantages of integrating 3D printing and nanotechnology in order to improve the safety of your nano-scale materials for biomedical applications


Engineers, academics, students, clinicians and professionals in biomedical engineering, medical devices, tissue engineering, and biomaterials

Table of Contents

  • List of Contributors
  • Preface
  • Chapter 1: Nanotechnology: A Toolkit for Cell Behavior
    • Abstract
    • 1.1. Introduction
    • 1.2. Nanobiomaterials for Tissue Regeneration
    • 1.3. 3D Nano/Microfabrication Technology for Tissue Regeneration
    • 1.4. Conclusion and Future Directions
    • Acknowledgments
  • Chapter 2: 3D Printing and Nanomanufacturing
    • Abstract
    • 2.1. Introduction
    • 2.2. 3D Printing and Nanomanufacturing Techniques
    • 2.3. Biomaterials Used with Additive Biomanufacturing Techniques
    • 2.4. Cells and Bioapplications
    • 2.5. Discussion: Pros and Cons of Each Technique
    • 2.6. Summary
  • Chapter 3: 3D Bioprinting Techniques
    • Abstract
    • 3.1. Introduction
    • 3.2. Definition and Principles of 3D Bioprinting
    • 3.3. 3D Bioprinting Technologies
    • 3.4. Challenges and Future Development of 3D Bioprinting
    • 3.5. Conclusion
  • Chapter 4: The Power of CAD/CAM Laser Bioprinting at the Single-Cell Level: Evolution of Printing
    • Abstract
    • 4.1. Introduction
    • 4.2. Basics of Laser-Assisted Printing: Overview of Systems and Critical Ancillary Materials
    • 4.3. MAPLE-DW Mechanics
    • 4.4. Cell Viability
    • 4.5. Case Studies and Applications Illustrating the Importance of Single-Cell Deposition
    • 4.6. Conclusion
  • Chapter 5: Engineering 2D and 3D Cellular Microenvironments Using Laser Direct Write
    • Abstract
    • 5.1. Introduction
    • 5.2. Materials in LDW
    • 5.3. LDW Applications in 2D
    • 5.4. LDW Applications in 3D
    • 5.5. Conclusions and Future Directions
    • Acknowledgments
  • Chapter 6: Biomaterials for Bioprinting
    • Abstract
    • 6.1. Introduction
    • 6.2. Parameters for Bioprinting
    • 6.3. Hydrogel Cross-Linking Mechanism
    • 6.4. Hydrogels in Bioprinting
    • 6.5. Integrative Support Materials
    • 6.6. Conclusion
  • Chapter 7: Blood Vessel Regeneration
    • Abstract
    • 7.1. Introduction
    • 7.2. Future Directions
    • Acknowledgments
  • Chapter 8: 3D Printing and Patterning Vasculature in Engineered Tissues
    • Abstract
    • 8.1. Introduction
  • Chapter 9: Craniofacial and Dental Tissue
    • Abstract
    • 9.1. Introduction
    • 9.2. Clinical Need for Craniofacial and Dental Regenerative Medicine
    • 9.3. Craniofacial and Dental Regenerative Medicine Research
    • 9.4. Bone Tissue Engineering Strategies
    • 9.5. Conclusions
    • Acknowledgment
  • Chapter 10: Craniofacial Bone
    • Abstract
    • 10.1. Introduction
    • 10.2. Craniofacial Bone Structure
    • 10.3. Different 3D Printing Techniques and Their Application to Craniofacial Scaffolds
    • 10.4. Nanotechnology in Craniofacial Graft Design
    • 10.5. Summary
  • Chapter 11: Additive Manufacturing for Bone Load Bearing Applications
    • Abstract
    • 11.1. Need for Bone Substitutes
    • 11.2. Compositional, Structural and Mechanical Properties of Bone
    • 11.3. Difficulties in Achieving an Ideal Bone Substitute
    • 11.4. Metallic Bone Substitutes
    • 11.5. Bioceramic Bone Substitutes
    • 11.6. Nanocomposite Bone Substitutes
    • 11.7. Conclusions
  • Chapter 12: Cartilage 3D Printing
    • Abstract
    • 12.1. General Introduction
    • 12.2. Future Directions
    • Acknowledgments
  • Chapter 13: Bioprinting for Skin
    • Abstract
    • 13.1. Skin, Skin Substitutes, Possible Applications for Printed Skin
    • 13.2. Epidermis
    • 13.3. Research
    • 13.4. Conclusion
    • Acknowledgments
  • Chapter 14: Nanotechnology and 3D Bioprinting for Neural Tissue Regeneration
    • Abstract
    • 14.1. Introduction
    • 14.2. Nanotechnology for Neural Tissue Regeneration
    • 14.3. 3D Bioprinting for Neural Tissue Regeneration
    • 14.4. Conclusion and Future Directions
    • Acknowledgments
  • Chapter 15: Organ Printing
    • Abstract
    • 15.1. Introduction
  • Chapter 16: Intellectual Property in 3D Printing and Nanotechnology
    • Abstract
    • 16.1. Introduction
    • 16.2. Why is Intellectual Property Important?
    • 16.3. Types of Intellectual Property
    • 16.4. Where does Intellectual Property Law Originate?
    • 16.5. What Aspects of 3D Bioprinting and Nanotechnology are Protectable?
    • 16.6. Intellectual Property Protection Limitations for Engineered Tissue
    • 16.7. Ethical Considerations of Engineered Tissue Intellectual Property
    • 16.8. Intellectual Property Infringement
    • 16.9. Conclusion
  • Index


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© Academic Press 2015
6th January 2015
Academic Press
Hardcover ISBN:
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About the Authors

Lijie Grace Zhang

Dr. Zhang received the Early Career Award from the International Journal of Nanomedicine, the John Haddad Young Investigator Award by American Society for Bone and Mineral Research, Ralph E. Powe Junior Faculty Enhancement Award by the Oak Ridge Associated Universities Organization, Joukowsky Family Foundation Outstanding Dissertation Award at Brown and the Sigma Xi Award. Dr. Zhang’s research areas include 3D bioprinting, nanobiomaterials, complex tissue engineering, stem cell engineering, drug delivery and breast cancer bone metastasis

Affiliations and Expertise

Assistant Professor, Director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering, Dept. of Mechanical and Aerospace Engineering and Dept.of Medicine, The George Washington University

John P Fisher

Dr. Fisher is the Director of the Tissue Engineering and Biomaterials Laboratory and investigates biomaterials, stem cells, and bioreactors for the regeneration of lost tissues, particularly bone, cartilage, vasculature, and skeletal muscle. The lab is supported by research grants from NIH, FDA, NSF, and other institutions, and has produced approximately 90 publications, 200 scientific presentations, and 8 patents. Dr. Fisher has been the research advisor to 11 Ph.D. students, 3 M.S. students, and over 50 undergraduate researchers. In 2012 Dr. Fisher was elected Fellow of the American Institute for Medical and Biological Engineering. Dr. Fisher is currently the Editor-in-Chief of the journal Tissue Engineering, Part B: Reviews, and in 2014 will co-chair the TERMIS-AM Meeting in Washington, DC

Affiliations and Expertise

Fischell Family Distinguished Professor and Associate Chair, Fischell Department of Bioengineering, University of Maryland

Kam Leong

Dr. Leong has published over 280 peer-reviewed research manuscripts and owns more than 50 issued patents. His work has been recognized by a Young Investigator Research Achievement Award of the Controlled Release Society, Distinguished Scientist Award of the International Journal of Nanomedicine, and Clemson Award for Applied Research of the Society for Biomaterials. He is the Editor-in-Chief of Biomaterials, and also a member of the National Academy of Engineering.

Affiliations and Expertise

Samuel Y. Sheng Professor, Department of Biomedical Engineering, Columbia University

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