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	HANDBOOK OF CARCINOGEN TESTING, SECOND EDITION To order this title, and for more information, click here Second Edition Edited By Harry A. Milman, National Cancer Institute, USA Elizabeth K. Haber, National Cancer Institute, USA By Harry A. Milman, National Cancer Institute, USA Elizabeth K. Haber, National Cancer Institute, USA Description In 1961 the National Cancer Institute initiated a program to conduct bioassays of selected compounds to determine whether they might be carcinogens. Although some similarities continue with the program as it was in 1961, there are many more differences. Since 1985 when the first edition of this book appeared, these differences have been substantial enough to merit an updated version. This updated edition will provide the reader with an overview of how to proceed with the various tests and how the data are eventually used for regulatory decisions. Audience Policymakers on the federal, state, and local levels in regards to legislating on carcinogens. Contents Part I. Predicting Carcinogenicity of Chemicals from Their Structure 1. Structural and Functional Criteria for Suspecting Chemical Compounds of Carcinogenic Activity: State-of-the-Art of Predictive Formalism Part II. Epidemiological Investigations 2 . Role of Epidemiology in Identifying Chemical Carcinogens Part III. In Vitro Tests 3. Overview of In Vitro Test for Genotoxic Agents 4. The Salmonella Mutagenicity Assay for Identification of Presumptive Carcinogens 5. Detection of Carcinogens Based on In Vitro Mammalian Cytogenetic Tests 6. Methods and Modifications of the Hepatocyte Primary Culture/DNA Repair Test 7. Cell Transformation Assays 8. The Importance of Alternatives to Animal Testing Part IV. Limited Bioassays 9. Rat Liver Foci Assay 10. Lung Tumors in Strain A Mice as a Bioassay for Carcinogenicity 11. Tumorigenesis of the Rat Mammary Gland 12. SENCAR Mouse Skin Tumorigenesis Part V. Long-Term Animal Bioassays 13. Design of a Long-Term Animal Bioassay for Carcinogenicity 14. Chemistry Requirements for Toxicological and Carcinogenicity Evaluation of Chemicals 15. Management and Handling of Hazardous Chemicals in the Laboratory 16. Conduct of Long-Term Animal Bioassays 17. Selection and Use of the B6C3F1 Mouse and F344 Rat in Long-Term Bioassays for Carcinogenicity 18. Adequacy of Syrian Hamsters for Long-Term Animal Bioassays 19. Quality Assurance in Pathology for Rodent Carcinogenicity Studies 20. Statistical Evaluation of Long-Term Animal Bioassays for Carcinogenicity 21. Considerations in the Evaluation and Interpretation of Long-Term Animal Bioassays for Carcinogenicity 22. The Significance of Preneoplastic Lesions in Rodent Bioassays 23. The Role of Immunotoxicity in Carcinogen Testing Part VI. Bioassays for Insoluble Materials 24. Bioassays for Asbestos and Other Solid Materials Part VII. Assays with Potential Utility 25. In Vitro Assay to Detect Inhibitors of Intercellular Communication 26. Alpha-Fetoprotein: A Marker for Exposure to Chemical Hepatocarcinogens in Rats 27. Ornithine Decarboxylase as a Marker of Carcinogenesis 28. Assay for Hepatic Peroxisome Proliferation to Select a Novel Class of Non-Mutagenic Hepatocarcinogens Part VIII. Risk Estimation 29. Examination of Risk Estimation Models 30. Risk Assessment: Biological Considerations 31. Exposure Assessment as a Component of Risk Assessment 32. Development of Methods for Chemical Carcinogen-DNA Adduct Determination in Human Tissues 33. Comparative Risk Assessment and Environmental Priorities 34. Some Aspects of Comparative Risk Assessment 35. Economic Considerations in the Risk Management of Chemical Carcinogens 36. Risk Communication and Risk Perception Part IX. Regulatory Implications 37. Regulatory Implication: Perspective of the U.S. Environmental Protection Agency 38. New Approaches to the Regulation of Carcinogens in Foods: The Food and Drug Administration 39. Workplace Carcinogens: Regulatory Implications of Investigations 40. Evaluation of Carcinogens: Perspective of the Consumer Product Safety Commission 41. Carcinogen Testing and Cancer Policy Framework of the Agency for Toxic Substances and Disease Registry 42. International Perspectives on Carcinogenicity Testing - A Brief Overview 43. International Aspects of Testing for Carcinogenicity and Regulation: A Selected Bibliography Part X. Industry Perspective 44. An Industrial Perspective on Testing for Carcinogenicity Index Bibliographic details Hardbound, 904 pages, publication date: DEC-1994 ISBN-13: 978-0-8155-1356-8 ISBN-10: 0-8155-1356-9 Imprint: WILLIAM ANDREW Price and Ordering Price: USD 185 GBP 100 EUR 146 Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). USD prices apply to the Americas and Asia Pacific. 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