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	CANCER IMMUNOTHERAPY Immune Suppression and Tumor Growth To order this title, and for more information, click here Edited By George Prendergast, Lankenau Institute for Medical Research, Wynnewood, PA, U.S.A. Elizabeth Jaffee, Department of Oncology, SKCCC, Johns Hopkins University, Baltimore, MD, U.S.A. Description There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. Audience Basic, translational, and clinical cancer researchers as well as practicing oncologists and their patients Contents Part I: Principles of Cancer Immunobiology Introduction Cancer Immunoediting: From Immune Surveillance to Immune Escape Immunosurveillance: Innate and Adaptive Anti-Tumor Immunity Cytokine Regulation of Immune Tolerance to Tumors Immunological Sculpting: Natural Killer Cell Receptors and Ligands Immune Escape: Immunosuppressive Networks Part II: Cancer Therapeutics Cytotoxic Chemotherapy in Clinical Treatment of Cancer Targeted Therapeutics in Cancer Treatment Concepts in Pharmacology and Toxicology Cancer Immunotherapy: Challenges and Opportunities Cancer Vaccines Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating Immune Suppression Immunotherapy and Cancer Therapeutics: Why Partner? Immune Stimulatory Features of Classical Chemotherapy Dendritic Cells and Co-Inhibitory Molecules Regulatory T Cells in Tumor Immunity: Role of Toll-like Receptors Tumor-associated Macrophages in Cancer Growth and Progression Tumor-associated Myeloid-derived Suppressor Cells Programmed Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune Escape IDO in Immune Escape: Regulation and Therapeutic Inhibition Arginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune Modulation Summary: Future Questions Bibliographic details Hardbound, 428 pages, publication date: JUN-2007 ISBN-13: 978-0-12-372551-6 ISBN-10: 0-12-372551-8 Imprint: ACADEMIC PRESS Price and Ordering Price: GBP 57.99 USD 99.95 EUR 82.95 Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). USD prices apply to the Americas and Asia Pacific. EUR prices apply in Europe and the Middle East. GBP prices apply to the UK and all other countries. See also information about conditions of sale & ordering procedures, and links to our regional sales offices. 092/942 Last update: 27 Sep 2008	Book contents Table of contents Reviews View other people's reviews Submit your review Bookmark this page Recommend this publication Overview of all books