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| DESIGN AND OPTIMIZATION IN ORGANIC SYNTHESIS, 24
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 Second Revised and Enlarged Edition
To order this title, and for more information, click here
By
Rolf Carlson, University of Tromsoe, Tromsoe, Norway
Johan Carlson, EISLAB, Luleå University of Technology, Luleå, Sweden
Included in series
Data Handling in Science and Technology, 24
Description
Revised, and updated Design and Optimization in Organic Synthesis presents strategies to explore experimental conditions and methodologies
for systematic studies of entire reaction systems (substrates, reagent(s), catalyst(s), and solvents). Chemical phenomena are not usually
the result of a single factor and this book describes how statistically designed methods can be used to analyse and evaluate synthetic
procedures. The methodology is based on multivariate statistical techniques. The accompanying CD contains data tables and programmes.
This book is essential reading for anyone working in process design and development in fine chemicals or the pharmaceutical industry,
and is suitable for those with no experience in the field.
Audience
Engineers working in process design and development. Chemical Engineers working in fine chemicals and the pharmaceutical industry. Organic Chemists and Chemometricians
Contents
Chapter 1: Introduction: Strategies on different levels in organic synthesis.
Chapter 2: Experimental study of reaction conditions.
Initial remarks.
Chapter 3: Models as tools.
Chapter 4: General outline of screening experiments.
Chapter 5: Two-level
factorial designs.
Chapter 6: Two-level fractional factorial designs.
Chapter 7: Other designs for screening experiments.
Chapter 8: Summary of screening experiments.
Chapter 9: Optimisation.
Chapter 10: Steepest ascent.
Chapter 11: Simplex
methods.
Chapter 12: Response surface methods.
Chapter 13:Reaction kinetics by sequential response
surface modelling.
Chapter 14: Summary of strategies for exploring the
experimental space.
Chapter 15: The reaction space.
Chapter 16: Principal
properties.
Chapter 17: Strategies for the selection of test systems.
Chapter 18: Quantitative relations: Observed responses
and experimental variations.
Chapter 19: Exploring discrete variations: Near-orthogonal experiments by singular value.
Chapter
20: Optimisation when there are several response variables.
Chapter 21: A method for determining suitable order of introducing reagents
in "one-pot" procedures.
Chapter 22: Books, journals, and computer programs.
Chapter 23: Concluding remarks.
Appendix
A: Matrix calculus.
Appendix B: Statistical tables.
| Bibliographic details |
Hardbound, 596 pages, publication date: APR-2005
ISBN-13: 978-0-444-51527-8
ISBN-10: 0-444-51527-5
Imprint: ELSEVIER
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| Price and Ordering |
Price:
USD 335
EUR 295
GBP 200
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Last update: 27 Sep 2008
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