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| THE HEART IN SYSTEMIC AUTOIMMUNE DISEASES, 1
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Andrea Doria
Paolo Pauletto
Ronald Asherson, Killarney, Johannesburg, South Africa
Included in series
Handbook of Systematic Autoimmune Diseases, 1
Description
This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune
diseases comprise a family of conditions that share common pathogenetic mechanisms as well as a multi-organ involvement including the
heart. This volume has been subdivided into three parts. In the first part, the immune mechanisms involved in cardiac damage have been
considered. The role of proinflammatory and regulatory cytokines in driving an autoimmune response to cardiac self-tissues has been analysed.
Moreover, the prevalence, the clinical meaning and the hypothetical pathogenicity of a broad spectrum of organ and non-organ specific
autoantibodies have been discussed in detail. In the second part of the volume, the role of humoral and innate immunity in promoting
the development of atherosclerotic plaque has been extensively reviewed, along with the newly discovered anti-inflammatory properties
of statins. These two parts of the volume deal with exciting aspects of this topic, suggesting a very close connection between heart
diseases and immunology. Finally, in the third part, the cardiac manifestations observed in the major systemic autoimmune conditions
have been comprehensively examined.
This book yields an impressive body of well ordered information, highlighting key references and
summarising the experience of a selected panel of distinguished physician-scientists actively involved in the field of cardiovascular
disease and systemic autoimmunity.
Contents
Part I. Immune and autoimmune mechanisms involved in cardiac damage.
Cellular immunity: A role for cytokines (D-L.Fearweather,
M. Afanasyeva, N.R. Rose). Humoral immunity: Organ-specific autoimmunity involvement in cardiovascular disease (A.L.P. Caforio, F. Tona,
W.J. McKenna). Humoral immunity: Non-organ specific autoimmunity (P. Riboldi, M. Gerosa et al.). Pathogenesis of Anti-SSA/Ro-SSB/La
associated congenital heart block (R.M. Clancy, J.P. Buyon).
Part II. Immune mechanisms involved in atherosclerosis.
Innate immunity, inflammation, and atherogenesis (M. Rattazzi, Y. Shoenfeld, P. Pauletto). Atherosclerosis and autoimmunity (Y.
Sherer, Y. Shoenfeld). Statins and autoimmunity (V.S. Gurevich).
Part III. Cardiac involvement in autoimmune connective
tissue diseases.
Cardiac imaging techniques in systemic autoimmune diseases (M. Turiel, P. Sarzi-Puttini, R. Cervera). Cardiac
involvement in rheumatoid arthritis (N.T. Goodson). Cardiac involvement in systemic lupus erythematosus (A. Doria, M. Petri). Neonatal
lupus syndrome: clinical features (A. Brucato, J. Buyon). The heart in scleroderma (G. Coghlan, C. Denton). Autoimmune myositis and overlap
syndrome (I. Lundberg). Cardiac involvement in the antiphospholipid syndrome (D.
Erkan, M. Roman et al.). Vasculitis (C. Pagnoux,
L. Boiardi et al.).
| Bibliographic details |
Hardbound, 276 pages, publication date: JAN-2004
ISBN-13: 978-0-444-51398-4
ISBN-10: 0-444-51398-1
Imprint: ELSEVIER
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| Price and Ordering |
Price:
USD 195
GBP 110
EUR 155
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Last update: 27 Sep 2008
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