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| MOLECULAR BIOLOGY OF B CELLS
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 To order this title, and for more information, click here
Edited By
Tasuku Honjo, Kyoto University, Japan
Frederick Alt, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA
Michael Neuberger, Medical Research Council Laboratory of Molecular Biology
Description
Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody
production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding
of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is
directed at research level immunologists, molecular biologists and geneticists.
Audience
Research level immunologists, molecular biologists and geneticists
Contents
ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENES
Human Immunoglobulin heavy chains locus
Immunoglobulin heavy
chain genes of mouse
Immunoglobulin – genes of human and mouse
Immunoglobulin lambdav (IGL) genes of human and mouse
The Mechanism of
V(D) J Recombination
Transcription of Immunoglobulin genes
B CELLS AND THEIR DEVELOPMENT
Early B cell development to a mature
, antigen-sensitive cell - cellular stages and molecular decisions
Allelic exclusion, Isotypic exclusion and the Developmental Regulation
of V(D)J Recombination
The Development of Human B Lymphocytes
Development and function of B cell subsets
B CELL DIFFERENTIATION INDUCED
BY Ag STIMULATION
Structure and function of B cells antigen receptor complexes
Regulation of antigen receptor signaling by the co-receptors,
CD19 and CD22
The dynamic structure of antibody responses
Dynamics of B cell migration to and within secondary lymphoid organs
Characteristics
of mucosal B cells with emphasis on the human secretory immune system
The Cellular Basis of B Cell Memory
Immunoglobulin assembly and
secretion
Fc And Complement Receptors
Ig GENE ALTERATION IN PERIPHERY
Regulation of Class Switch Recombination
Molecular Mechanism
of Class Switch Recombination
Molecular Mechanism of Hypermutation
Selection During Antigen-Driven B Cell Immune Responses: The Basis
for High Affinity Antibody
DISEASES OF B CELLS
Chromosomal Translocations in B-cell Leukemias and Lymphomas
Classification and
Characteristics of Mouse B Cell-Lineage Lymphomas
B cells producing pathogenic autoantibodies
Immunodeficiencies Caused by B Cell Defects
EVOLUTION OF Ig GENES
Diverse forms of Immunoglobulin Genes in Lower Vertebrates
Immunoglobulin Genes and Generation of Antibody
Repertoires in Higher Vertebrates: A Key Role for GALT
The zebrafish immune system
The Origin of V(D)J Diversification
FUNCTION AND
APPLICATION OF IMMUNOGLOBULINS
Antibody Structure and Recognition of Antigen
Monoclonal antibodies from display libraries
Humanization
of Monoclonal Antibodies
Human monoclonal antibodies from translocus mice
Bibliographic & ordering Information
Hardbound, 600 pages, publication date: DEC-2003
ISBN-13: 978-0-12-053641-2
ISBN-10: 0-12-053641-2
Imprint: ACADEMIC PRESS
Price: Order form
GBP 105
EUR 147
USD 190
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Last update: 29 Aug 2008
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