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LACTOFERRIN: STRUCTURE, FUNCTION AND APPLICATIONS
Lactoferrin: Structure, Function and ApplicationsProceedings of the 4th International Conference on Lactoferrin: Structure, Function and Applications, Sapporo, Japan, 18-22 May 1999

Edited by
K. Shimazaki, Hokkaido University, Dairy Science Laboratory, Faculty of Agriculture, Kita 9, Nishi 9, Kita-ku, Sapporo, Hokkaido, Japan
H. Tsuda, National Cancer Center Research Institute, Experimental Pathology & Chemotherapy Division, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
M. Tomita, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa 228-8583, Japan
T. Kuwata, Meiji Milk Products Co., Ltd., Nutrition Science Institute, 1-21-3, Sakae-machi, Higashimurayama, Tokyo 189-8530, Japan
J.P. Perraudin, Biopole S.A., 7S Bv Ed. Machtens, Brussels 1080, Belgium

Included in series
International Congress, 1195

Description
This book is a collection of research performed on the lactoferrin using different themes related to the biological role of the molecule. Main features include the role of lactoferrin in the immune system, and the inflammatory response and the similarity of the activities of the human lactoferrin and bovine lactoferrin on the human cells.

Audience
Scientists working in immunology, inflammation, cancer and viruses

Contents


Structure and Interaction.
Lactoferrin three-dimensional structure: a framework for interpreting function (H.M. Baker et al.). Identification of two molecular species in human milk-derived lactoferrin (S.-M. Yang et al.). Structural studies of lactoferricin B and its antimicrobial active peptide fragments (D.J. Schibli, H.J. Vogel). Approach to identification and comparison of the heparin-interacting sites of lactoferrin using synthetic peptides (K. Shimazaki et al.). Interaction of lactoferrin with calcium and its implications to application of lactoferrin in foods (M.Y. Xu et al.).

Lactoferrin Receptors.
Bacterial lactoferrin receptors (A.B. Schryvers, H. Wong). Brain lactoferrin: origins and mechanisms of accumulation in neurodegenerative disorders (C. Fillebeen et al.). Binding of human lactoferrin to Escherichia coli porins: a biochemical study (F.R. Sallmann et al.).

Anti-inflammation.
Lactoferrin and regulation of cutaneous immunity and inflammation (I. Kimber et al.). Lactoferrin, endotoxin, and nitric oxide metabolism in pulmonary alveolar macrophages (M. Sherman et al.). Antiinflammatory effect of lactoferrin in mouse models of arthritic disease (C. Guillen et al.). Plasma lactoferrin concentration measured by ELISA in healthy and diseased cows (R. Sato et al.).

Immunomodulating effects.
Anti-inflammatory and immunoregulatory properties of lactoferrin (J.H. Brock, C. Guillen, C. Thompson). Comparative studies of human and bovine lactoferrins effects on the immune system (I. Dhennin-Duthille et al.). Is nitric oxide involved in the protective effect against Escherichia coli infection generated by lactoferrin in vivo? (T. Zagulski, M. Zimecki, M.L. Kruzel). Lactoferrin protects against the development of hepatitis caused by LPS-induced TNF-alpha production (H. Sasaki et al.). Identification of an active domain of bovine lactoferrin that enhances the phagocytic activity of human neutrophils (H. Miyauchi et al.). Regulatory effect of bovine lactoferricin in the cell cycle in human monocytic THP-1 cells (Y.-C. Yoo et al.).

Anti-microbial activities.
Importance of pathogen-eliminating systems in host protection by lactoferrin feeding (M. Tomita et al.). Antiviral activity of lactoferrin derived peptides (P. Valenti et al.). Lactoferrin against oral candidiasis (J.J.M. van den Berg et al.). Augmentation by lactoferrin of host defense against candida infection in mice (S. Abe et al.). In vitro and in vivo anti-dermatophytic effects of lactoferrin (H. Wakabayashi et al.). Effects of lactoferrin administration in Helicobacter pylori infection animal model (N. Shimizu et al.). Role of glycan chains in bovine lactoferrin (G. Antonini et al.). Antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells (M. Ikeda et al.). Antiviral effect of bovine lactoferrin on feline herpesvirus infection (N. Hirano et al.). Bovine lactoferrin is more efficient than bovine lactoferricin in inhibiting HSV-I / -II replication in vitro (J. Hammer, H. Haaheim, T.J. Gutteberg).

Lactoferrin gene and recombinant proteins.
Lactoferrin gene: methylation, expression and cancer (C.T. Teng, D.J. Grant, M. Negishi). Expression of recombinant mouse lactoferrin in insect cells (M. Matsuura et al.). Production of human lactoferrin in transgenic plants (H. Anzai, F. Takaiwa, K. Katsumata). Expression of lactoferricin from Korean native cattle in yeast (K. Kim et al.). Genomic human lactoferrin sequence induced high levels of protein expression in milk of transgenic mice (S.J. Kim et al.).

Lactoferrin metabolism.
Clinical studies in lactoferrin added to infant formula (B. Lönnerdal). Lactoferrin and insult-induced metabolic imbalance in humans and other animals (M.L. Kruzel, T. Zagulski, M. Zimecki) Digestion of orally administered lactoferrin in adult rats (H. Kuwata et al.). Bio-distribution of human lactoferrin in the gastrointestinal tract (S. Khan et al.).

Pathology and clinical applications.
Antimicrobial and antitumor activities of lactoferrin in mouse model systems (R. Bhimani, Y. Vendrov, P. Furmanski). Isolation and detection of human lactoferrin binding protein in human amniotic membrane (K. Otsuki et al.). Role of lactoferrin on the prevention of preterm delivery (H. Saito et al.). Effect of lactoferrin on human endometrial cell proliferation (A. Yanaihara et al.). Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C (K. Tanaka et al.). Lactoferrin as component of localized amyloidosis of the seminal vesicle of the aged (Y. Tsutsumi). Clinical evaluation of orally administered bovine lactoferrin for treatment of tinea pedis (K.Yamauchi et al.). Effect of lactoferrin on iron absorption in mice (T. Hagiwara et al.). Prevention of carcinogenesis and metastasis by dietary bovine lactoferrin (H. Tsuda et al.). Bovine lactoferrin inhibits rat tongue carcinogenesis (T. Tanaka et al.).

Commercial applications and others.
Human lactoferrin: production at large scale, characterization and applications (D.R. Headon). Lactoferrin improves physiological conditions of fish held under deteriorating states (I. Kakuta). Effect of bovine lactoferrin on performance of Japanese flounder Paralichthys olivaceus (F.J. Gallardo-Cigarroa et al.). Effect of lactoferrin on growth, survival and tolerance to stress of kuruma praown Penaeus japonicus (S. Koshio et al.). Concluding remarks (E.N. Baker).

Index of authors. Keyword index.


Bibliographic & ordering Information
Hardbound, 478 pages, publication date: APR-2000
ISBN-13: 978-0-444-50317-6
ISBN-10: 0-444-50317-X
Imprint: EXCERPTA MEDICA
Price: Order form
USD 142
GBP 94.50
EUR 142

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Last update: 14 Jul 2008
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