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| COMMON DISEASE - GENETIC AND PATHOGENETIC ASPECTS OF MULTIFACTORIAL DISEASES
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 Proceedings of the Uehara Memorial Foundation Symposium 1999, Tokyo, Japan, 30 June-2 July 1999
Edited by
H. Imura, Chairman of the Organizing Committee, Executive Member, Prime Minister's Council for Science and Technology. Prime Minister's Office,
Government of Japan, 2-1, Kasumigaseki 2-chome, Chiyoda-ku, Tokyo 100-8966, Japan
M. Kasuga, Vice Chairman of the Organizing Committee, Professor and Chairman, Second Department of Internal Medicine, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ko, Kobe 650-0017, Japan
K. Nakao, Professor and Chairman, Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
Included in series
International Congress, 1181
Description
Designated as the "common diseases," hypertension, diabetes mellitus type 2, obesity, dyslipidemia, arteriosclerosis and gout, are becoming
the most important world-wide health problems, requiring intensive research in order to better understand their pathogeneses, and to
administer proper preventive measures. This book contains the proceedings of the Uehara Memorial Foundation Symposium 1999, a collection
of 29 outstanding contributions from the most eminent experts in the field of genetics and pathogenetics. It is divided into 5 sessions:
Adipogenesis and Obesity, Diabetes Mellitus, Hyperlipidemia, Hypertension and General Molecular Biology in Common Disease.
Common
Disease: Genetic and Pathogenetic Aspects of the Multifactorial Diseases will provide an excellent source to all professionals who
would like to acquire information on the latest cutting-edge developments in genetics and pathogenetics of multifactorial diseases such
as obesity, hyperlipidemia, hypertension and diabetes mellitus.
Audience
Professionals in the field of Cardiology & Cardiovascular Medicine: Atherosclerosis, Hypertension & Cardiology; Endocrinology
and Metabolism; Molecular Biology: Gene Structure Expression and Regulation, Molecular Medicine; Genetics: Human Genetics, Molecular
Epidemiology, Molecular Genetics and Molecular Evolution; Public, Environmental and Occupational Health: Epidemiology
Contents
Preface.
Pathogenesis of common diseases viewed from an evolutionary standpoint
(H. Imura).
Adipogenesis and Obesity.
Leptin and the neural circuit regulating body weight
(J.M. Friedman).
Potential usefulness of leptin for the treatment of diabetes
(K. Nakao et al.).
Critical early events of Adipogenesis
(G. Ailhaud et al.).
Molecular mechanism of obesity-related
diseases: importance of adipocytokines
(Y. Matsuzawa et al.).
Diabetes Mellitus.
The role of pancreatic β-cell
ATP-sensitive K+ channels in insulin secretion
(S. Seino et al.).
Downstream effectors of PI 3-kinase in insulin action
(M.
Kasuga et al.).
Insulin signaling and the molecular mechanisms of insulin resistance
(C.R. Kahn).
Role of PPARγ in high-fat
diet induced adipocyte hypertrophy and insulin resistance
(T. Kadowaki et al.).
Variability of clinical features of HNF-1α-deficient
diabetes (MODY3) due to different functional properties of mutant proteins
(J.Takeda et al.).
Positional cloning of Wolfram
Syndrome (diabetes mellitus and optic atrophy) gene: its role in pancreatic β cell survival
(Y. Oka).
Studies of the etiology of
type 2 diabetes mellitus in Pima Indians
(C. Bogardus et al.).
Maturity-onset diabetes of the young: A model for genetic studies
of diabetes mellitus
(G.I. Bell et al.).
Hyperlipidemia.
Common susceptibility genes to dyslipidemia and coronary heart
disease in Japanese people
(H. Hamaguchi et al.).
Degradation enzymes for sterol regulatory element binding protein
(H. Shirai et al.).
Molecular and physiological studies of the HDL receptor SR-BI
(B. Trigatti).
Molecular basis for cellular cholesterol
efflux and regulation of plasma HDL level
(S. Yokoyama et al.).
PPARα: cross-talk with membrane receptors and control of
energy homeostasis
(W. Wahli et al.).
Peroxisome proliferator-activated receptor γ, the ultimate liaison between fat and
transcription
(S. Rocchi, J. Auwerx).
Regulation of macrophage gene expression and lipid metabolism by the Nuclear Receptor PPARγ
(P. Tontonoz, L. Nagy, R.M. Evans).
Hypertension.
Genetics of essential hypertension
(A.M. Sharma).
Genetic susceptibility
to essential hypertension in Japanese people
(T. Katsuya et al.).
Mapping nephropathy susceptibility genes using kidney specific
chromosome transfer
(P.C. Churchill et al.).
Genetic analysis of spontaneously hypertensive rats (SHR), an animal model of
hypertension and insulin resistance
(T. Gotoda, Y. Iizuka, N. Yamada).
Roles of LOX-1, an endothelial oxidized low-density lipoprotein
receptor, in vascular disorders
(M. Nagase, K. Ando, T. Fujita).
Genetic analysis of endothelial nitric oxide synthase in patients with
coronary spasm
(H. Sue et al.).
General molecular biology in common disease.
Genomic searches for Genes that influence
common disease in human and nonhuman primate families
(J.E. Hixson).
Roles of prostanoids in health and disease: lessons from receptor-knockout
mice
(S. Narumiya).
Index of authors.
Keyword index.
Bibliographic & ordering Information
Hardbound, 284 pages, publication date: DEC-1999
ISBN-13: 978-0-444-50200-1
ISBN-10: 0-444-50200-9
Imprint: EXCERPTA MEDICA
Price: Order form
USD 138
EUR 138
GBP 92
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Last update: 22 Jul 2008
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