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 The Molecular Mechanism and Volume Sensing Machinery
Proceedings of the 23rd Taniguchi Foundation Biophysics Symposium, Okazaki, Japan, 17-21 November 1997
Edited by
Y. Okada, National Institute of Physiological Sciences, Department of Cellular and Molecular Physiology, Myodaiji-cho, Okazaki, Japan
Included in series
International Congress, 1160
Description
Cell volume regulation is of fundamental importance to animal cells, since persistent swelling or shrinkage results in cell death. Osmotic
perturbation confronts the cells with
the problem of volume regulation, because most animal cell membrane are highly permeable to water.
A number of cellular physiological activities are associated with osmotic perturbation to cells. Those include active solute uptake by
enterocytes, renal tubular cells or hepatocytes,
fluid and electrolyte secretion by glandular cells, cell mitogenesis or proliferation,
cell differentiation, hormonal action on hepatocytes, lymphocytes or cardiac myocytes, excitation in neurons, and glutamate receptor
activation in brain neurons or glial cells. Also, in kidney medulla and intestinal tissues, not only epithelial cells but also blood
and mesenchymal cells may be subject to osmotic stress induced by increased extracellular osmolality.
Under pathological conditions,
cell volume perturbations are caused either by plasma osmolality changes due to a major complication in various disorders (such as diabetes
mellitus, renal failure, congenital heart failure and hepatic cirrhosis) or by the cell content increase due to ischemia, hypoxia or
metabolic disturbance. Disorders of body fluid
osmolality may also be induced by iatrogenic insults (especially by intravenous administration
of water or osmolytes). Brain cell volume also changes in association with neuropathological states. Furthermore, it has become evident
that impairments of cell volume regulation are closely associated with necrotic or apoptotic cell death. Thus, to manage these pathophysiological
states, studies on the mechanisms of cell volume regulation and on the modulators for volume-regulatory machinery including volume-sensitive
C1- channels should provide crucially important information.
Audience
Life scientists
Contents
Preface.
Contributors.
Part I. Volume Sensor and Volume Regulation.
How do red blood cells know how big they are?(J.R. Sachs).
Volume sensor anion channel
(Y. Okada et al.).
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is involved
in
mechano-signal transduction in endothelial cells (M. Masuda et al.).
Neural volume regulation of single guinea-pig cardiac
myocytes
(T. Mitsuiye, A. Noma).
Regulatory volume decrease in cultured brain cells: rate limiting factors
(H. Pasantes-Morales,
C.V. Morales-Mulia, O. Quesada).
Cell volume in the regulation of metabolism, cell proliferation and apoptotic cell
death (F. Lang et al.).
Part II. Cellular Signalling Associated with Volume Regulation.
Activation of cellular signalling pathways
by hypotonicity
(B.C. Tilly, T. van der Wiji, H.R. de Jonge).
Dual calcium response to cell volume change in aortic endothelium
(M. Oike et al.).
Ionic mechanisms of RVD in A6 cells: SA channel, [CA2+]i, whole cell currents, and
RVD
(M. Sokabe, W. Yu, K, Takemoto).
Cause and roles of mechanical stress in mammary gland
(K. Furuya, H. Nakano, K. Enomoto).
ATP release from swollen or CFTR-expressing epithelial cells
(A. Hazama et al.).
Molecular mechanism of stress-induced
cardiac hypertrophy
(I. Komuro et al.).
Part III. Ion Channel and Transporter Involved in Volume Regulation.
Cell
volume regulation: the role of chloride channels
(T.J.C. Jacob, L. Wang, L. Chen).
Electrophysiological properties of volume-regulated
Cl- channels in intestinal
epithelial cells
(S. Oiki, M. Kubo, Y. Okada).
Is ICln a swelling dependent chloride channel?
(M.
Gschwentner et al.).
Volume-regulated anion channels in vascular endothelium
(B. Nilius et al.).
Molecular machineries
of the neonatal rat kidney against osmotic stress
(K. Kawahara, N. Anzai, I. Isumida).
Cloning and properties of a hypertonicity-inducible
inward rectifier K+ channel from
euryhaline eels
(Y. Suzuki et al.).
The Na+/H+ exchanger and volume regulation
(S. Wakabayashi et al.).
Part IV. Organic Osmolyte Transporter and Water Channel Involved in Volume Regulation.
Transcriptional regulation
of transporters for compatible osmolytes by hypertonicity
(H.M. Kwon).
Urinary concentrating defect and organic osmolytes
(T. Nakanishi et al.).
Hypotonic and high K+ media swelling-induced release of excitatory amino-acids
from brain astrocytes
(H.K. Kimelberg,
E.M. Rutledge).
Structure and regulation of the aquaporin water channels
(K. Fushimi, S. Sasaki, F. Marumo).
Water movement during
cell volume regulation
(S. Morishima et al.).
Index of Authors.
Bibliographic & ordering Information
Hardbound, 230 pages, publication date: JUL-1998
ISBN-13: 978-0-444-82951-1
ISBN-10: 0-444-82951-2
Imprint: EXCERPTA MEDICA
Price: Order form
USD 135
EUR 135
GBP 90
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Last update: 14 Jun 2008
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