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	BIOENERGETICS To order this title, and for more information, click here Third Edition By David Nicholls, Buck Institute, Novato, California, U.S.A. Stuart Ferguson, University of Oxford, U.K. Description This new edition of Bioenergetics presents a clear and up-to-date explanation of the chemiosmotic theory and covers mitochondria, bacteria, and chloroplasts. It takes account of the many newly determined structures, such as ATP synthase and the two photosystems of photosynthesis, that provide molecular insight into chemiosmotic energy transduction. This edition includes additional color figures of protein structures and many newly drawn illustrations designed to enable the reader to grasp the fundamental insights that are derived from knowing the structure. Every chapter has been extensively revised and updated and a new chapter on the study of the bioenergetics of mitochondria in the intact cell is included to satisfy the enormous interest in this topic. Written for students and researchers alike, this book is the most current text on the chemiosmotic theory and membrane bioenergetics available. Audience Undergraduates, graduates, postgraduates, and researchers working in biochemistry and the biological sciences. Contents Preface Note to the Reader Glossary CHEMIOSMOTIC ENERGY TRANSDUCTION Introduction The Chemiosmotic Theory: Fundamentals The Basic Morphology of Energy-Transducing Membranes Overview ION TRANSPORT ACROSS ENERGY-CONSERVING MEMBRANES Introduction The Classification of Ion Transport Bilayer-Mediated Transport Protein-Catalyzed Transport Swelling and the Co-ordinate Movement of Ions Across Membranes QUANTITATIVE BIOENERGETICS: THE MEASUREMENT OF DRIVING FORCES Introduction Gibbs Energy and Displacement from Equilibrium Oxidation-Reduction (Redox) Potentials Ion Electrochemical Potential Differences Photons Bioenergetic Interconversions and Thermodynamic Constraints on their Stoichiometries The Equilibrium Distributions of Ions, Weak Acids and Weak Bases Membrane Potentials, Diffusion Potentials, Donnan Potentials and Surface Potentials THE CHEMIOSMOTIC PROTON CIRCUIT Introduction The Measurement of Protonmotive Force The Stoicheiometry of Proton Extrusion by the Respiratory Chain The Stoicheiometry of Proton Uptake by the ATP Synthase Proton Current and Respiratory Control Proton Conductance Mitochondrial Respiration Rate and Metabolic Control Analysis Overall Parameters of Energy-Transduction Reversed Electron Transfer and the Proton Circuit Driven by ATP Hydrolysis ATP Synthesis Driven by an Artificial Protonmotive Force Kinetic Competence of Ap in the Proton Circuit Light-dependent ATP Synthesis by Bovine Heart ATP Synthase RESPIRATORY CHAINS Introduction Components of the Mitochondrial Respiratory Chain The Sequence of Redox Carriers in the Respiratory Chain The Mechanism of Electron Transfer Proton Translocation by the Respiratory Chain; "loops" or "conformational pumps" or both? Complex I (NADH-UQ Oxidoreductase) Delivering Electrons to Ubiquinone without Proton Translocation Ubiquinone and Complex III (bc1 or UQ-Cyt c Oxidoreductase) Cytochrome c and Complex IV (Cytochrome c Oxidase; Ferrocytochrome c; O2 Oxidoreductase) Overall Proton and Charge Movements Catalysed by the Respiratory Chain: Correlation with the P/O Ratio Superoxide Production by Complex I and III Oxidative Stress The Nicotinamide Nucleotide Transhydrogenase Electron Transport in Mitochondria of Non-Mammalian Cells Bacterial Resporatory Chains PHOTOSYNTHETIC GENERATORS OF PROTONMOTIVE FORCE Introduction The Light Reaction of Photosynthesis in Rhodobacter sphaeroides and Related Organisms The Generation by Illumination or Respiration of Ap in Photosynthetic Bacteria The Electron-Transfer and Light-Capture Pathway in Green Plants and Algae Bacteriorhodpsin and Halorhodopsin THE ATP SYNTHASE Introduction F1 and F0 The Subunits of the F1F0-ATPase The Structure of F0 F1 Enzymology of ATP Synthase Relating the Structure to Function for ATP Synthase Non-Thermodynamic Regulation of the ATP Synthase Proton Translocation by Other ATPases and Pyrophosphatases METABOLITE AND ION TRANSPORT Introduction Mitochondrial Cation Transporters Mitochondrial Metabolite Transporters The Transfer of Electrons from Cytoplasmic NADH to the Respiratory Chai The Phosphate and Adenine Nucleotide Transporters The Uncoupling Protein Family Bacterial Transport Transport (Movement) of Bacterial Cells Transport of Macromolecules Across Membranes MITOCHONDRIA IN THE CELL Introduction Monitoring A?m and ATP Synthesis in Intact Cells Mitochondria and Cellular Ca2+ Homeostasis Mitochondria and Programmed Cell Death Mitochondria and Necrotic Cell Death The Mitochondrial Genome Import and Assembly of Mitochondrial Proteins Mitochondrial Genetic Diseases Mitochondrial Involvement in Neurodegenerative Diseases References Appendix Index Bibliographic & ordering Information Paperback, 288 pages, publication date: JUL-2002 ISBN-13: 978-0-12-518121-1 ISBN-10: 0-12-518121-3 Imprint: ACADEMIC PRESS Price: Order form USD 69.95 GBP 39.99 EUR 57.95 Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). 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