The Nobel Prize in Chemistry 2009
This year the Nobel Prize in Chemistry was divided between
"for studies of the structure and function of the ribosome."
In recognition of the importance of their work, we are pleased to make the laureates’ key articles published with Elsevier freely available:
Thomas Steitz
The structural changes of T7 RNA polymerase from transcription initiation to elongation Current Opinion in Structural Biology , In Press, Corrected Proof, Article in Press 5 October 2009
A structural view on the mechanism of the ribosome-catalyzed peptide bond formation Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2009, Article in Press
U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:. The Structures of Tiamulin, Homoharringtonine, and Bruceantin Bound to the Ribosome Journal of Molecular Biology , Volume 389, Issue 1, 29 May 2009, pp. 146-156
Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant
Journal of Molecular Biology , Volume 379, Issue 3, 6 June 2008, pp. 505-519
Structure of the Base of the L7/L12 Stalk of the Haloarcula marismortui Large Ribosomal Subunit: Analysis of L11 Movements Journal of Molecular Biology , Volume 371, Issue 4, 24 August 2007, pp. 1047-1059
The Geometry of the Ribosomal Polypeptide Exit Tunnel
Journal of Molecular Biology , Volume 360, Issue 4, 21 July 2006, pp. 893-906
The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit Journal of Molecular Biology , Volume 340, Issue 1, 25 June 2004, pp. 141-177
Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit Journal of Molecular Biology , Volume 330, Issue 5, 25 July 2003, pp. 1061-1075
The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and Girodazole Journal of Molecular Biology , Volume 367, Issue 5, 13 April 2007, Pages 1471-1479
Venkatraman Ramakrishnan
Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: Structure of the proteins and their interactions with 16 S RNA
Brodersen , D.E., Clemons Jr., W.M., Carter, A.P., Wimberly, B.T., Ramakrishnan, V.
The termination of translation
Current Opinion in Structural Biology , Volume 18, Issue 1, February 2008, pp. 70-77.
Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: Purification, crystallization and structure determination Journal of Molecular Biology , Volume 310, Issue 4, 20 July 2001, pp. 827-843.
Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance Journal of Molecular Biology , Volume 279, Issue 4, 19 June 1998, Pages 873-888
Ribosomal Protein L9: A Structure Determination by the Combined Use of X-ray Crystallography and NMR Spectroscopy Journal of Molecular Biology , Volume 264, Issue 5, 20 December 1996, Pages 1058-1071
Positions of proteins S14, S18 and S20 in the 30 S ribosomal subunit of Escherichia coli Journal of Molecular Biology , Volume 174, Issue 2, 5 April 1984, Pages 265-284
Positions of proteins S6, S11 and S15 in the 30 S ribosomal subunit of Escherichia coli Journal of Molecular Biology , Volume 153, Issue 3, 15 December 1981, Pages 739-760
Ada E. Yonath
The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery
Research in Microbiology , Article in Press, Corrected Proof, Available online 18 July 2009
A crevice adjoining the ribosome tunnel: Hints for cotranslational folding
FEBS Letters , Volume 57,Issue 15, 13 June 2005, pp. 3207-3213
From peptide-bond formation to cotranslational folding: Dynamic, regulatory and evolutionary aspects FEBS Letters , Volume 579, Issue 4 SPEC. ISS., 7 February 2005, pp. 948-954.
Ribosomal crystallography: A flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism FEBS Letters , Volume 567, Issue 1, 1 June 2004, pp. 20-26.
Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression Molecular Cell , Volume 11, Issue 1, January 2003, pp. 91-102.
On the interaction of colicin E3 with the ribosome Biochimie , Volume 84, Issue (5-6), May-June 2002, pp. 447-454.
Ribosomal crystallography: From poorly diffracting microcrystals to high-resolution structures Methods , Volume 25, Issue 3, November 2001, pp. 292-302.
Some X-ray diffraction patterns from single crystals of the large ribosomal subunit from Bacillus stearothermophilus Journal of Molecular Biology , Volume 177, Issue 1, 25 July 1984, Pages 201-206
Single crystals of large ribosomal particles from Halobacterium marismortui diffract to 6 Å Journal of Molecular Biology , Volume 193, Issue 4, 20 February 1987, Pages 819-822
Characterization and preliminary attempts for derivatization of crystals of large ribosomal subunits from Haloarcula marismortui diffracting to 3 Å resolution Journal of Molecular Biology , Volume 222, Issue 1, 5 November 1991, Pages 11-15
Characterization and preliminary crystallographic studies on large ribosomal subunits from Thermus thermophilus Journal of Molecular Biology , Volume 216, Issue 2, 20 November 1990, Pages 239-241
Crystals of wild-type, mutated, derivatized and complexed 50 S ribosomal subunits from Bacillus stearothermophilus suitable for X-ray analysis Journal of Molecular Biology , Volume 205, Issue 3, 5 February 1989, Pages 619-621
Characterization of single crystals of the large ribosomal particles from a mutant of Bacillus stearothermophilus
Journal of Molecular Biology , Volume 192, Issue 1, 5 November 1986, Pages 161-162
Characterization of single crystals of the large ribosomal particles from Bacillus stearothermophilus Journal of Molecular Biology , Volume 187, Issue 4, 20 February 1986, Pages 633-636
Electron Cryomicroscopy of Bacillus stearothermophilus 50 S Ribosomal Subunits Crystallized on Phospholipid Monolayers Journal of Molecular Biology , Volume 239, Issue 5, 23 June 1994, Pages 689-697
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