Volume 11: Nervous System and Behavioral Toxicology
Edited by H.E. Lowndes K.R. Reuhl
Description
Neurotoxicology is among the fastest growing of the toxicological disciplines. Recent refinements of neuropathologic techniques, meticulous
validation of behavioral tests, and introduction of the tools of molecular biology have led to rapid progress in our understanding of
the mechanisms and consequences of neurotoxic injury. This volume is intended to provide the reader with an appreciation of the scope
of approaches taken in the mechanistic study of neurotoxic agents. The volume's 31 chapters, each contributed by recognized experts,
are divided into three sections. Section 1 addresses the basic anatomical and biochemical components of the nervous system, with special
attention placed on those areas where existing or emerging data have demonstrated toxic actions. This section is directed towards the
nonspecialists, offering overviews of topics in neuroscience, as well as contemporary reviews of selected topics for researchers in the
field. Section 2 focuses on neurobehavioral toxicology and alterations of the special issues. Specific behavioral domains and the functional
consequences of their perturbation are discussed in detail. Particular emphasis has been given to research methodologies in neurobehavioral
toxicology especially the appropriate use, limitations, and interpretations. Section 3 provides a survey of selected classes of compounds
demonstrated to have adverse effects on nervous system structure and function. It is intended to provide current reviews of chemical-specific
neurotoxicity for practitioners in neurotoxicity.
Contents
Fundamentals of the structure and function of the nervous system (G.D. Zeevalk). Selective vulnerability in the nervous system (T.A.
Sarafian, A.M. Verity). Degenerative and regenerative events in the central and peripheral nervous systems (E.D. Hall). Neurotoxicant-induced
oxidative events in the nervous system (S. Bondy). Cytoskeletal elements in neurotoxicity (S.J. Pyle). Role of cell signaling in neurotoxicity
(L.G. Costa). Cell adhesion molecules as targets of neurotoxicants (K.R. Reuhl, G.B. Grunwald). Neurotransmitter receptors (A.T. Eldefrawi,
M. Eldefrawi). Ion channels (T. Narahashi). Phosphoprotein phosphatases as potential mediators of neurotoxicity (E.F. da Cruz e Silva,
J.P. O'Callaghan). Myelin and myelinating cells as affected by toxicants (P. Morell, A.D. Toews). Glial cells (M.A. Philbert, M. Aschner).
Behavioral screening for neurotoxicity (V.C. Moser). Neural, behavioral, and measurement considerations in the detection of motor impairment
(M.C. Newland). Somatosensory neurotoxicity: agents and assessment methodology (D.C. Rice). Intermittent schedules of reinforcement as
toxicological end points (D.A. Cory-Slechta). Learning and memory (H.A. Tilson). The developing nervous system (W. Slikker, Jr). Nervous
system and behavioral toxicology (N. Fiedler). The role of behavior in the assessment of toxicity (B. Weiss). Toxicology of the neuromuscular
junction (W.D. Atchison). Auditory toxicology (L.D. Fechter, Y. Liu). Olfactory system (D.C. Dorman, J.G. Owens, K.T. Morgan). In
vivo systems: animal models of neurological diseases (T.J. Walsh). In vitro systems in neurotoxicological studies (G.J.
Audesirk). Anticholinesterases insecticides (D. J. Ecobichon). Organochlorine and pyrethroid insecticides (R.M. Joy). Lead (E.X. Albuquerque,
K.L. Swanson, M. Marchiora, K. Ishihara, M. Alkondon, E.F.R. Pereira). Neurotoxicology of heavy metals (L.W. Chang). Botanical neurotoxins
(M. Pass). Excitotoxicity (M. Flint Beal).
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