Edited by R.A. Roth, Michigan State University, East Lansing, MI, USA
Description
Volume 8 begins with a detailed description of the functional anatomy of the various regions and critical cells of the respiratory
tract, from the nasal cavity to the gas exchange region. This section conveys the structural heterogeneity of the respiratory system
and how it determines tissue and cellular targets for toxic agents. The next section describes functional and biochemical responses of
the lungs to toxic insult and includes chapters on carcinogenic and developmental responses to chemical exposure. The final section comprises
over 20 chapters describing injurious effects of selected chemicals of toxicologic interest. Human health concerns as well as mechanisms
of toxicity are emphasized. Unlike other volumes that have treated this subject, attention is devoted to effects of toxic agents on both
the airways and the pulmonary vasculature.
Contents
Introduction (R.A. Roth). Nasal airways (J.R. Harkema). Tracheobronchial airways (K.E. Pinkerton, K.P. Avadhanam, J.L. Peake, C.G.
Plopper). Pulmonary blood vessels (ie. conducting vessels only) (N.F. Voelkel, R.M. Tuder). Alveolar epithelium in lung toxicology (L.-Y.
Chang, J.D. Crapo). Vascular endothelium and the lungs (M.J. Block, E.A. Drab, D.B. Rubin). The air/blood interface: connective tissue
and interstitium (S.N. Giri, Q. Wang). Inflammatory cells of the lung: macrophages (A. Holian). Inflammatory cells of the lung: polymorphonuclear
leukocytes (D.M. Hyde, A. Sterner-Kock). Pulmonary mechanical function and gas exchange (D.L. Costa, J.S. Tepper). Biochemical function
of lungs: clearance of circulating, endogenous agents (I.G. Horvath E. Tzoufi, J.D. Catravas). Biochemical function of lungs: metabolism
of xenobiotic agents (A.R. Buckpitt, M.K. Cruikshank). Carcinogenic responses of the respiratory tract (F.F. Hahn). Pulmonary developmental
responses to toxicants (M. Voit Fanucchi, C.G. Plopper). Mucus and surfactant (T. Honda, K. Kubo, T. Kobayashi). Cell damage and cell
renewal in the lung (H.P. Witschi). In vitro systems for studying respiratory system toxicology (E.M. Postlethwait, A. Bidani). Ozone
(L. van Bree, J.A. Last). Oxygen toxicity (L. Frank). Oxides of nitrogen (M.J. Utell, M.W. Frampton). Sulfur oxides (R.B. Schlesinger,
I. Jaspers). Aldehydes (H. d'A. Heck). Coal dust (V. Castranova, B.S. Ducatman). Crystalline silica and silicosis (K.E. Driscoll, G.D.
Guthrie). Asbestos (A.R. Brody). Organic dusts (R.C. Rylander). Etiology of occupational asthma (TDI, plastic monomers, red cedar, etc.)
(L. Fabbri, G. Caramori, P. Maestrelli). Carcinogenic effects of cigarette smoke on the respiratory tract (S.S. Hecht). Noncarcinogenic
effects of cigarette smoke on the respiratory tract (T.J. Gronski Jr, S.D. Shapiro). Radon (J.M. Samet). Toxicity of airborne metals
(D.E. Gardner, J.A. Graham). Nuisance dusts (R.O. McClellan). The pulmonary toxicity of chemotherapeutic agents (K. Ramu, J.P. Kehrer).
Bleomycin-induced pulmonary fibrosis (D. G. Hoyt, J.S. Lazo). Cationic, amphiphilic drugs (M.J. Reasor). Pyrrolizidine alkaloids (C.M.
Hoorn). Paraquat (L.L. Smith). Selected, nontherapeutic agents (3MI, ANTU, 2-naphthol, 3MF, 4IP, etc.) (G.S. Yost). Bacterial endotoxin
(R. Burrell).
Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). USD prices apply to the Americas. EUR prices apply in Europe. GBP prices apply to the UK and all other countries. Customers who order on-line from the Americas will be invoiced in USD and all other countries will be invoiced in GBP.
