Description Sj?gren?s syndrome, an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva,
afflicts somewhere between 1 and 4 million people in the United States. This issue of Rheumatic Disease Clinics of North America examines
the clinically important aspects of this disorder and features articles on the following topics: pathogenesis; hepatitis C involvement;
measurement of disease activity; relationship to other autoimmune disorders; involvement of the respiratory tract; involvement of the
nervous system; lymphoma and Sj?gren?s syndrome; fatigue; optimizing dry mouth treatment; management of dry eye; issues in DMARD and
biological therapy; and therapeutic potential for B-cell modulation.
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