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| MIMS' MEDICAL MICROBIOLOGY
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With STUDENT CONSULT Online Access
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Fourth Edition
By
Richard Goering, MD, PhD, Professor, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, USA
Hazel Dockrell, MD, Professor of Immunology, London School of Hygiene and Tropical Medicine, London, UK
Mark Zuckerman, MB, BS(London), MSc, BSc, MRCP, MRCPath, Consultant Virologist, South London PHL and Department of Infection, Department of Virology, King's College Hospital NHS Trust, London, UK
Derek Wakelin, BSc, PhD, DSc, FRCPath, University of Nottingham, Nottingham, UK
Ivan Roitt, MA, DSc(Oxon), Hon FRCP(Lond), FRCPath, FRS, Emeritus Professor of Immunology, Director of Institute of Biomedical Science, University College London Medical School, London, UK
Cedric Mims, BSc, MD, FRCPath, Guy's Hospital Medical School, London, UK
Peter Chiodini, Honorary Professor, Infectious & Tropical Diseases, The London School of Hygiene and Tropical Medicine; Consultant Parasitologist, Dept. of Clinical Parasitology, Hospital for Tropical Diseases
Description
MIMS' MEDICAL MICROBIOLOGY offers thorough and up-to-date coverage of microbiology and basic immunology, through a clinically relevant,
systems-based approach. The textbook emphasises the microbiology of the agents causing disease, and the diseases affecting individual
organ systems. Through thorough cross referencing, the reader can easily find what they need, whether seeking information from a systems
or a microbe perspective. Nearly 500 illustrations support the text, and summary introductory and summary key facts boxes strengthen
the clarity and usefulness of the text.
Contents
1. Microbes as parasites
– The varieties of microbes
– Living inside or outside cells
– Systems of classification
2.
The bacteria
– Structure
– Nutrition
– Growth and division
– Gene expression
– Extrachromosomal elements
–
Mutation and gene transfer
– Survival under adverse conditions
– The genomics of medically important bacteria
3.
The viruses
– Infection of host cells
– Replication
– Outcome of viral infection
– Major groups of viruses
4.
The fungi
– Major groups of disease-causing fungi
5. The protozoa
6. The helminths and arthropods
–
The helminths
– The arthropods
7. Prions
– ?Rogue protein' pathogenesis
– Development and transmission
of prion diseases
– Medical problems posed by prion disease
8. The host?parasite relationship
– The
normal flora
– Symbiotic associations
– The characteristics of parasitism
– The evolution of parasitism
9. The
innate defenses of the body
– Defense against entry into the body
– Defenses once the microorganism penetrates the
body
10. Adaptive responses provide a ?quantum leap' in effective defense
– The role of antibodies
–
The role of T lymphocytes
– Extracellular attack on large infectious agents
– Local defenses at mucosal surfaces
11.
The cellular basis of adaptive immune responses
– B and T cell receptors
– Clonal expansion of lymphocytes
– The
role of memory cells
– Stimulation of lymphocytes
– Cytokines
– Regulatory mechanisms
– Tolerance mechanisms
12.
Background to the infectious diseases
– Host?parasite relationships
– Causes of infectious diseases
– The biologic
response gradient
13. Entry, exit and transmission
– Sites of entry
– Exit and transmission
– Types
of transmission between humans
– Transmission from animals
14. Immune defenses in action
– Complement
–
Acute phase proteins and pattern recognition receptors
– Fever
– Natural killer cells
– Phagocytosis
– Cytokines
– Antibody-mediated
immunity
– Cell-medited immunity
– Recovery from infection
15. Spread and replication
– Features
of surface and systemic infections
– Mechanisms of spread through the body
– Genetic determinants of spread and replication
–
Other factors affecting spread and replication
16. Parasite survival strategies and persistent infections
–
Parasite survival strategies
– Concealment of antigens
– Antigenic variation
– Immunosuppression
– Persistent infections
17.
Pathologic consequences of infection
– Pathology caused directly by the microorganism
– Pathologic activation of natural
immune mechanisms
– Pathologic consequences of the immune response
– Skin rashes
– Viruses and cancer
Introduction to
Section 4: The Clinical Manifestations of Infection
18. Upper respiratory tract infections
– The common
cold
– Pharyngitis and tonsillitis
– Parotitis
– Otitis and sinusitis
– Acute epiglottitis
– Oral cavity infections
–
Laryngitis and tracheitis
– Diphtheria
19. Lower respiratory tract infections
– Acute infections
–
Chronic infections
– Parasitic infections
20. Urinary tract infections
– Acquisition and etiology
–
Pathogenesis
– Clinical features and complications
– Laboratory diagnosis
– Treatment
– Prevention
21. Sexually
transmitted diseases
– STDs and sexual behavior
– Syphilis
– Gonorrhea
– Chlamydial infection
– Other causes
of inguinal lymphadenopathy
– Mycoplasmas and non-gonococcal urethritis
– Other causes of vaginitis and urethritis
– Genital
herpes
– Human papillomavirus infection
– Human immunodeficiency virus
– Opportunistic STDs
– Arthropod infestations
22.
Gastrointestinal tract infections
– Diarrheal diseases caused by bacterial or viral infection
– Food poisoning
–
Helicobacter pylori and gastric ulcer disease
– Parasites and the gastrointestinal tract
– Systemic infection initiated in the
gastrointestinal tract
23. Obstetric and perinatal infections
– Infections occurring in pregnancy
–
Congenital infections
– Infections occurring around the time of birth
24. Central nervous system infections
–
Invasion of the central nervous system
– The body's response to invasion
– Meningitis
– Encephalitis
– Neurologic diseases
of possible viral etiology
– Spongiform encephalopathy caused by scrapie-type agents
– CNS disease caused by parasites
– Brain
abscesses
– Tetanus and botulism
25. Infections of the eye
– Conjunctivitis
– Infection of the deeper
layers of the eye
26. Infections of the skin, soft tissue, muscle and associated systems
– Bacterial infections
of skin, soft tissue and muscle
– Mycobacterial diseases of the skin
– Fungal infections of the skin
– Parasitic infections
of the skin
– Mucocutaneous lesions caused by viruses
– Smallpox
– Measles
– Rubella
– Other infections producing skin
lesions
– Kawasaki syndrome
– Viral infections of muscle
– Parasitic infections of muscle
– Joint and bone infections
–
Infections of the hemopoietic system
27. Vector-borne infections
– Arboviruses infections
– Infections
caused by Rickettsiae
– Borrelia infections
– Protozoal infections
– Helminth infections
28. Multisystem zoonoses
–
Arenavirus infections
– Korean hemorrhagic fever
– Marburg and Ebola hemorrhagic fevers
– Q fever
– Anthrax
– Plague
–
Yersinia enterocolitica infection
– Tularemia
– Pasteurella multocida infection
– Leptospirosis
– Rat bite fever
– Brucellosis
–
Helminth infections
29. Fever of unknown origin
– Definitions of fever of unknown origin
– Causes of
FUO
– Investigation of classical FUO
– Treatment of FUO
– FUO in specific patient groups
– Infective endocarditis
30.
Infections in the compromised host
– The compromised host
– Infections of the host with deficient innate immunity
due to physical factors
– Infections associated with secondary adaptive immunodeficiency
– Other important opportunist pathogens
31.
Strategies for control: an introduction
– Epidemiologic considerations
– Detection and diagnosis
– Chemotherapy
versus vaccination
– Control versus eradication
32. Diagnosis of infection and assessment of host defense mechanisms
–
Aims of the clinical microbiology laboratory
– Specimen processing
– Non-cultural techniques for the laboratory diagnosis of infection
–
Cultivation (culture) of microorganisms
– Identification of microorganisms grown in culture
– Antibody detection methods for the
diagnosis of infection
– Assessment of host defense systems
– Protocols for specimen processing
33. Attacking the
enemy: antimicrobial agents and chemotherapy
– Selective toxicity
– Discovery and design of antibacterial agents
–
Classification of antibacterial agents
– Resistance to antibacterial agents
– Classes of antibacterial agents
– Inhibitors of
cell wall synthesis
– Inhibitors of protein synthesis
– Inhibitors of nucleic acid synthesis
– Antimetabolites affecting nucleic
acid synthesis
– Other agents that affect DNA
– Inhibitors of cytoplastic membrane function
– Urinary tract antiseptics
–
Antituberculous agents
– Antibacterial agents in practice
– Antibiotic assays
– Antiviral therapy
– Antifungal agents
–
Antiparasitic agents
– Use and misuse of antimicrobial agents
34. Vaccination
– The aims of vaccination
–
Requirements of a good vaccine
– Types of vaccine
– Special considerations
– Community-based control by vaccination
– Factors
influencing the success of vaccination
– Current vaccine practice
35. Passive and non-specific immunotherapy
–
Passive immunization with antibody
– Non-specific cellular immunostimulation
– Correction of host immunodeficiency
36.
Hospital infection, sterilization and disinfection
– Common hospital-acquired infections
– Important causes of hospital
infection
– Sources and routes of spread of hospital infection
– Host factors and hospital infection
– Consequences of hospital
infection
– Prevention of hospital infection
– Investigating hospital infection
– Sterilization and disinfection
Appendix – Pathogen parade
Answers
Index
| Bibliographic details |
Paperback, 668 pages, publication date: OCT-2007
ISBN-13: 978-0-323-04475-2
ISBN-10: 0-323-04475-1
Imprint: MOSBY
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Last update: 25 Nov 2009
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