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Immune Suppression and Tumor Growth
To order this title, and for more information, click here
Edited By
George Prendergast, Lankenau Institute for Medical Research, Wynnewood, PA, U.S.A.
Elizabeth Jaffee, Department of Oncology, SKCCC, Johns Hopkins University, Baltimore, MD, U.S.A.
Description
There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This
book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can
be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent
studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular
targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides
basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how
applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced
disease.
Audience
Basic, translational, and clinical cancer researchers as well as practicing oncologists and their patients
Contents
Part I: Principles of Cancer Immunobiology
Introduction
Cancer Immunoediting: From Immune Surveillance to Immune Escape
Immunosurveillance: Innate and Adaptive Anti-Tumor Immunity
Cytokine Regulation of Immune Tolerance to Tumors
Immunological Sculpting:
Natural Killer Cell Receptors and Ligands
Immune Escape: Immunosuppressive Networks
Part II: Cancer Therapeutics
Cytotoxic
Chemotherapy in Clinical Treatment of Cancer
Targeted Therapeutics in Cancer Treatment
Concepts in Pharmacology and Toxicology
Cancer
Immunotherapy: Challenges and Opportunities
Cancer Vaccines
Part III: Targets and Tactics to Improve Cancer Immunotherapy By
Defeating Immune Suppression
Immunotherapy and Cancer Therapeutics: Why Partner?
Immune Stimulatory Features of Classical Chemotherapy
Dendritic Cells and Co-Inhibitory Molecules
Regulatory T Cells in Tumor Immunity: Role of Toll-like Receptors
Tumor-associated Macrophages
in Cancer Growth and Progression
Tumor-associated Myeloid-derived Suppressor Cells
Programmed Death Ligand-1 and Galectin-1: Pieces in
the Puzzle of Tumor Immune Escape
IDO in Immune Escape: Regulation and Therapeutic Inhibition
Arginase, Nitric Oxide Synthase, and Novel
Inhibitors of L-arginine Metabolism in Immune Modulation
Summary: Future Questions
| Bibliographic details |
Hardbound, 428 pages, publication date: JUN-2007
ISBN-13: 978-0-12-372551-6
ISBN-10: 0-12-372551-8
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
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USD 105
EUR 78.95
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092/942
Last update: 25 Nov 2009
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