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| COMPARATIVE CYTOARCHITECTONIC ATLAS OF THE C57BL/6 AND 129/SV MOUSE BRAINS WITH CD ROM
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Edited By
P. R. Hof, Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY, USA
W. G. Young, Department of Neuropharmacology, The Scripps Research Institute, Jolla, CA, USA
F. E. Bloom, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
P. V. Belichenko, Department of Neurology, Stanford University, Stanford, CA, USA
M. R. Celio, Institute of Histology and General Embryology, University of Fribourg, Perolles, Fribourg, Switzerland
Description
This atlas represents a first step in comparing the anatomic organization of the brains of the C57BL/6 and the 129/Sv mice, two substrains
that are frequently used in studies of the central nervous system. The mouse is rapidly becoming the most commonly used mammalian resource
in biomedicine. The need to model human diseases through genetic manipulation in transgenic animals, the existence of a wide array of
immunological markers for murine cell surface receptors, and the need to test new drugs has resulted in an increasing demand for inbred
rodents. To date, a very large number of genetically manipulated mouse models have been created, that have been derived from over 450
inbred strains. Whereas it is possible to control the expression of specific genes in these animals, relatively scarce information is
known on the comparative neuroanatomical characteristics of different strains of mice.
Such information is crucial for the interpretation
of scientific data obtained from genetically manipulated animals. Because many such genetically manipulated mice models are used in neuroscience,
it is important to document the differences in brain organization existing among different mouse strains.
Representative series of
49 levels for general cytoarchitecture and 6 levels for myeloarchitecture are presented in standard stereotaxic coordinates from the
brains of the C57BL/6 and the 129/Sv mice. This permits a comparison of the distribution of the various nuclei, cortical areas and fiber
tracts, and an assessment of the variability between the two strains. For each plate, an alphabetical list of structures, with the abbreviations
used in the plate and the full anatomical names of the structures is provided. An alphabetical index of structure names for each mouse
with relevant atlas pages is included as well as a comparative list of structures in alphabetical order with indication of the pages
and levels calculated from the bregma where structures occur. This permits a quick cross-reference of the extent and location of specific
brain structures between the two mice.
Matching CD-ROMs, containing all of the plates in Adobe Illustrator 8.0 format, structure lists
and comparative index are also provided.
In future this atlas will be enriched with brains of other mouse strains and eventually provide
comparative and quantitative, stereologic as well as immunohistochemical data on a series of relevant brain structures.
Contents
1. Introduction.
1.1. Objectives and general design of the atlas. 1.2. Biological and zoological characteristics
of mice. 1.3. Origin of the strains used in this atlas. 1.4. Major differences among strains commonly used in neuroscience.
2.
Materials and methods.
2.1. Mouse strains. 2.2. Preparation of the materials. 2.2.1. Stereotaxic approach. 2.2.2. Perfusion
and fixation. 2.2.3. Section processing and staining. 2.3. Production of the comparative plates. 2.3.1. Photography and outlining. 2.3.2.
Scanning and layering. 2.3.3. Tracing of structures and rendition. 2.3.4. Completing the plates. 2.3.5. Preparing and placing the stereotaxic
grids. 2.3.6. The CD-ROMs.
3. Acknowledgements.
4. References.
5. Atlas
of the brain of the C57BL/6 mouse:
49 Nissl (Cresyl Violet)- and 6 myelin (Luxol-Fast Blue)-stained plates; for each
plate: full art, half lineart, and list of relevant structures.
6. Atlas of the brain of the 129/Sv mouse:
49 Nissl (Cresyl Violet)- and 6 myelin (Luxol-Fast Blue)-stained plates; for each plate: full art, half lineart, and list of relevant
structures.
7. Index of structures.
7.1. Alphabetical lists of abbreviations by plate number. 7.1.1.
C57BL/6 mouse. 7.1.2. 129/SV mouse. 7.2. Alphabetical lists of abbreviations by page number. 7.2.1. C57BL/6 mouse. 7.2.2. 129/Sv mouse.
7.3. Comparative index of structures with bregma levels.
| Bibliographic details |
Hardbound, 284 pages, Hardbound A3 Atlas + 4 CD-ROMs - Available for PC and Macintosh, publication date: DEC-2000
ISBN-13: 978-0-444-50194-3
ISBN-10: 0-444-50194-0
Imprint: ELSEVIER
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| Price and Ordering |
Price:
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USD 160
GBP 131.50
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Last update: 10 Sep 2009
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