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Fourth Edition
Edited By
Kim Barrett, Professor of Medicine and Vice-Chair for Research, Department of Medicine, University of California, San Diego, San Diego, California, U.S.A.
Leonard Johnson, Vice Chancellor for Research and Thomas A. Gerwin Professor of Physiology, University of Tennessee, Memphis, USA
Fayez Ghishan, Horace W. Steele Endowed Chair in Pediatric Research Head, Department of Pediatrics Director, Steele Children's Research Center, Department
of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona, U.S.A.
Juanita Merchant, Professor of Internal Medicine and Integrative and Molecular Physiology, University of Michigan, Ann Arbor, Michigan, U.S.A.
Hamid Said, Professor of Medicine, Physiology and Biophysics, Departments of Medicine and Physiology/Biophysics, University of California School of Medicine, Irvine, California, U.S.A.
Jackie Wood, Professor of Physiology and Cell Biology and Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, U.S.A.
Description
FROM THE PREFACE:
The original purpose of the First Edition of Physiology of the Gastrointestinal Tract—to collect
in one set of volumes the most current and comprehensive knowledge in our field—was also the driving force for the Fourth Edition.
The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular
techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology
and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development,
apoptosis, and mechanisms in malignancies. Most of the chapters in this section were edited by Juanita L. Merchant. Section II has been
renamed "Neural Gastroenterology and Motility" and has been expanded from seven chapters with rather classic titles to more than twenty
chapters encompassing not only the movement of the various parts of the digestive tract but also cell physiology, neural regulation,
stress, and the regulation of food intake. Almost all of the chapters were recruited and edited by Jackie D. Wood. The third section
is entirely new and contains chapters on "Immunology and Inflammation" which were edited by Kim E. Barrett. The fourth section on the
"Physiology of Secretion" consists of chapters with familiar titles, but with completely updated information to reflect the advances
in our understanding of the cellular processes involved in secretion. The last section on "Digestion and Absorption" contains new chapters
on the intestinal barrier, protein sorting and ion channels along with those focusing on the uptake of specific nutrients. These chapters
were recruited and edited by Hamid M. Said and Fayez K. Ghishan.
Audience
Clinical gastroenterologists, Grad-level lecturer, American College of Gastroenterology members, Internists, and Physiologists
Contents
Section I: Basic Cell Physiology and Growth of the GI Tract
1. Transcription and Epigenetic Regulation Juanita
L. Merchant and Longchuan Bai
2. Translation and Posttranslational Processing of GI Peptides Cheryl E. Gariepy and Chris J.
Dickinson
3. Transmembrane Receptors for Endogenous Ligands and Associated SignalsNigel Bunnett
4. Gastrointestinal Hormones:
Gastrin, CCK, Somatostatin, Ghrelin Graham J. Dockray
5. Post-Pyloric Gastrointestinal Peptides Ella W. Englander and
George H. Greeley
6. GI Peptide Hormones Regulating Energy and Glucose Homeostasis Daniel J. Drucker
7. Growth Factors
in the GI Tract John Barnard and Kirk McHugh
8. Developmental Signaling Networks: The Wnt/APC/b-catenin pathway Eric Fearon
9. Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis Gijs R. van den Brink, Maikel P. Peppelenbosch,
and Drucilla J. Roberts
10. Developmental Signaling Networks: The Notch Pathway Guy R. Sander, Hanna Krysinska, and Barry
Powell
11. Physiology of Gastrointestinal Stem Cells Alda Vidrich, Jenny M. Buzan, Sarah A. De La Rue, and Steven M. Cohn
12. Apoptosis in the Gastrointestinal Tract Leonard R. Johnson
13. Molecular Aspects and Regulation of Gastrointestinal Function
During Post-Natal DevelopmentJames F. Collins, Liqun Bai, Hua Xu and Fayez K. Ghishan
14. Effect of Aging on the Gastrointestinal
Tract Adhip P.N. Majumdar and Marc D. Basson
15. Regulation of Gastrointestinal Normal Cell Growth Mark R. Hellmich and
B. Mark Evers
16. Mucosal Repair and Restitution Mark R. Frey and D. Brent Polk
17. Mechanisms of GI Malignancies John
P. Lynch and Anil K. Rustgi
Section II: Neural Gastroenterology and Motility
18. Development of Enteric Nervous
System Michael Gershon
19. Cellular Physiology of Gastrointestinal Smooth Muscle Gabriel M. Makhlouf and Karnam S. Murthy
20. Organization and Electrophysiology of Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastrointestinal Tract Kenton
M. Sanders, Sang Don Koh, and Sean M. Ward
21. Functional Histoanatomy of the Enteric Nervous System Simon JH Brookes and
Marcello Costa
22. Physiology of Prevertebral Sympathetic Ganglia Joseph H. Szurszewski and Steven M. Miller
23. Cellular
Neurophysiology of Enteric Neurons Jackie Wood
24. Integrative Functions of the Enteric Nervous System Jackie D. Wood
25. Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract Michael J. Beyak, David C.E. Bulmer, Wen Jiang, Christopher
D. Keating, Weifang Rong, and David Grundy
26. Processing of Gastrointestinal Sensory Signals in the Brain Anthony R. Hobson
and Qasim Aziz
27. Enteric Neural Regulation of Mucosal Secretion Helen J. Cooke and Fievos L. Christofi
28. Effect of
Stress on Intestinal Mucosal Function Johan D. Soderholm and Mary H. Perdue
29. Effect of Stress on Gastrointestinal Motility
Michele Gue
30. HPA-Axis In Gastrointestinal Physiology Yvette Tache
31. Neural Regulation of Gastrointestinal Blood
Flow Peter Holzer
32. Neural Control of the Gallbladder and Sphincter of Oddi Gary M. Mawe, Gino T.P. Saccone, and Maria
J. Pozo
33. Brainstem Control of the Gastric Function Richard C. Rodgers, Gerlinda E. Hermann, and R. Alberto Travagli
34. Neural and Hormonal Controls of Food Intake and Satiety Timothy H. Moran
35. Pharyngeal Motor Function Reza Shaker
36. Motor Function of the Esophagus Ray E. Clouse and Nicholas E. Diamant
37. Neurophysiological Mechanisms of Gastric Reservoir
Function Jan Tack
38. Small Intestinal Motility William L. Hasler
39. Large Intestinal Motility Sushil Sarna
40. Neural Control of Pelvic Floor Muscles David B. Vodusek and Paul Enck
41. Pathophysiology Underlying the Irritable Bowel
Syndrome Jackie D. Wood
Section III. Gastrointestinal Immunology and Inflammation
42. Innate Immune Responses
in the GI Tract: Sensors and Effectors Lars Eckmann
43. Biology of Gut Immunoglobulins Finn-Eirik Johansen, Elizabeth
Yen, Bonny Dickinson, Massaru Yoshida, Steve Claypool, Richard S. Blumberg, and Wayne I. Lencer
44. Mechanisms of Helicobacter pylori-induced
Gastric Inflammation Dawn A. Israel and Richard M. Peek Jr.
45. Mechanisms and Consequences of Intestinal
Inflammation in the GutWallace MacNaughton
46. Recruitment of Inflammatory and Immune Cells in the Gut: Physiology and Pathophysiology
D. Neil Granger, Christopher Kevil, and Matthew B. Grisham
47. Physiology of Host-Pathogen Interactions Kim Hodges, V.K.
Viswanathan and Gail Hecht
Section IV. Physiology of Secretion
48. Salivary Secretion David Cook
49. Regulation of Gastric Acid Secretion Arthur Shulkes, Graham S. Baldwin, and Andrew S. Giraud
50. Gastroduodenal Mucosal
Defense Marshall H. Montrose, Yasutada Akiba, Koji Takeuchi, and Jonathan D. Kaunitz
51. Genetically Engineered Mouse Models
of Gastric Physiology Linda C. Samuelson
52. Structure-Function Relationships in the Pancreatic Acinar Cell Fred S. Gorelick
and James D. Jamieson
53. Stimulus-Secretion Coupling in Pancreatic Acinar Cells John A. Williams and David I. Yule
54. Cell Physiology of Pancreatic Ducts B.E. Argent, M.A. Gray, M.C. Steward, and R.M. Case
55. Regulation of Pancreatic Secretion
Rodger A. Liddle
56. Bile Formation and the Enterohepatic Circulation Paul Dawson, Ben Shneider and Alan Hofmann
57. Mechanisms of Hepatocyte Organic Anion Transport Allan W. Wolkoff
58. Mechanisms of Hepatocyte Detoxification Karen
F. Murray, Donald J. Messner, and Kris V. Kowdley
59. Physiology of Cholangiocytes Anatoliy I. Masyuk, Tatyana V. Masyuk,
and Nicholas F. LaRusso
60. Gallbladder Function Sum P. Lee and Rahul Kuver
Section V. Digestion and Absorption
61. Tight Junctions and the Intestinal Barrier Thomas Y. Ma, and James M. Anderson
62. Protein Sorting in the Exocytic and
Endocytic Pathways in Polarized Epithelial Cells Stephen J. Hunt and W. James Nelson
63. Physiology of the Circulation of the
Small Intestine Philip T. Nowicki
64. Sugar Absorption Ernest M. Wright, Donald D. F. Loo, Bruce A. Hirayama, and Eric
Turk
65. Protein Digestion and Absorption Vadivel Ganapathy, Naren Gupta, and Robert G. Martindale
66. Lipid Digestion
and Absorption Judy Storch and Nada Abumurad
67. Genetic Regulation of Intestinal Lipid Transport and Metabolism Zhouji
Chen and Nicholas O. Davidson
68. Digestion and Intestinal Absorption of Dietary Carotenoids & Vitamin A Alexandrine During
and Earl H. Harrison
69. Vitamin D3: Synthesis, Actions, and Mechanisms in the Intestine and Colon J. Wesley Pike, Makoto Watanuki,
and Nirupama K. Shevde
70. Vitamin E and Vitamin K Metabolism Ronald J. Sokol, Richard Bruno, and Maret Traber
71. Intestinal
Absorption of Water-Soluble Vitamins Hamid M. Said and Bellur Seetharam
72. Water Transport in the Gastrointestinal Tract
Jay R. Thiagarajah and Alan S. Verkman
73. Na+/H+ Exchange in Mammalian Digestive Tract Pawel R. Kiela and Fayez K. Ghishan
74. Intestinal Anion Absorption Pradeep K. Dudeja and Krishnamurthy Ramaswamy
75. Ion Channels of the Epithelia of the Gastrointestinal
Tract John Cuppoletti and Danuta H. Malinowska
76. Integrated Physiology of Intestinal Electrolyte TransportKim Barrett
and Stephen Keely
77. Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium James F. Collins and
Fayez K. Ghishan
78. Iron Absorption Nancy C. Andrews
79. Trace Element Absorption and Transport Robert J. Cousins
Volumes
: Physiology of the Gastrointestinal Tract
Bibliographic & ordering Information |
- Physiology of the Gastrointestinal Tract
Hardbound, 2080 pages, publication date: MAR-2006
ISBN-13: 978-0-12-088394-3
ISBN-10: 0-12-088394-5
Imprint: ACADEMIC PRESS
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Price:
EUR 406.95
GBP 345
USD 570
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Last update: 3 Oct 2009
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