Edited by
G. Pattenden, University of Nottingham, UK
Description
Volume 3 covers carbon-to-carbon single bond forming reactions involving
sp
3,
sp
2 and
sp
carbon centers, but only those which do not involve additions to C-X π-bonds. The volume first compares and contrasts the alkylation
reactions of all types of
sp
3 carbon nucleophiles and also covers vinyl and alkynyl carbanions. Following on from
Volume 2, a separate section covers Friedel-Crafts alkylation reactions, which is complemented by discussions of polyene cyclizations
and electrophilic transannular cyclizations in synthesis. Coupling reactions leading to α-bond formation, and involving all types
of combinations of
sp
3,
sp
2 and
sp carbon centers are next covered, including those reactions
based on pinacol, acyloin and phenol oxidative coupling reactions, and also the Kolbe reaction. Rearrangement reactions, leading to carbon-to-carbon α-bond formation, are often used in a clever manner in synthesis. The volume includes all those rearrangement reactions based on
intermediate carbonium ions and carbanions, and also includes the benzil-benzilic acid and the Wolff rearrangements. The volume closes
with coverage of carbonylation reactions, and the use of carbene insertion reactions into the C-H bond in synthesis.
