Audience
Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.
Contents
Introduction
Clusterin (CLU): from one gene, at least two transcripts and many proteins. (F. Rizzi)
CLU expression
and cell signaling. (D.A. Boothman)
Nuclear CLU and cell cycle regulation, cell proliferation and apoptosis (S. Bettuzzi and
F. Rizzi)
Regulation of CLU expression by calcium (A. Orzechowski; Dr. B. Pajak)
The chaperone action of CLU (C. Koch-Brandt
and M.R. Wilson)
CLU, chronic inflammation and auto-immunity (G. Chiocchia)
CLU and Nf-kB action (A. Sala)
CLU,
a biosensor of increased oxidative stress (I. Trougakos and S. Gonos)
CLU and prostate cancer (S. Bettuzzi and M. Gleave)
CLU and breast cancer (D. A Boothman and M. Redondo)
CLU and colon cancer (S. Pucci and A. Thomas-Tikhonenko)
Involvement of CLU in acquisition of chemoresistance (J.Y. Djeu and A. Zoubeidi)
CLU, a neuprotectant factor (Pucci S.,
Nucci C., Ricci F)
CLU and tumorigenesis (S. Bettuzzi, D.A. Boothman, S. Pucci, A. Sala, A. Thomas-Tikhonenko)
Conclusions
and perspectives: a possible role for CLU in novel therapies and advanced diagnostic tools? (S. Bettuzzi)
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