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By Alexander McPherson
Edited By Ludke X
Audience
Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists
Contents Introduction; Analysis of genomes for structural genomics and the limitations of sequence analysis; Structure determination pipeline for
structural genomics;Gene cloning and protein expression;Gene cloning and expression of membrane proteins; High-throughput protein purification
for x-ray crystallography and NMR; High-throughput protein crystallization; Structure determination using synchrotron radiation; Application
of NMR to structural genomics; Development of key high-throughput technologies: High-throughput functional screening; Development of
key high-throughput technologies: Structure prediction and homology modeling; Functional inferences from structure; Structural genomics
programs (SARS case); Structural genomics programs (E.coli);Structural genomics as a structural foundation for drug discovery; Structural
genomics of eukaryote; Structural genomics of complexes; Dissemination structural genomics data to biology community
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