Comprehensive Medicinal Chemistry II

Volume 5: ADME-TOX APPROACHES

Comprehensive Medicinal Chemistry II on ScienceDirect(Opens new window)
Hardbound, 1181 Pages
Published: NOV-2006
ISBN 10: 0-08-044518-7
ISBN 13: 978-0-08-044518-2
Imprint: ELSEVIER


Edited by
Bernard Testa, University Hospital Centre, Lausanne, Switzerland
Han van de Waterbeemd, AstraZeneca, Macclesfield, Cheshire, UK

Description
To be effective a drug must be Absorbed then Distributed to the site of action. It must also be Metabolised and Excreted without any measurable Toxicity (ADMET). This volume examines major ADMET issues, tools to measure these properties in vivo and in vitro and in-silico tools to predict and analyse effects. It concludes with a review of tools that can assist drug discovery in its early development stage.



Audience:
For students and researchers in chemistry, biochemistry, medicinal chemistry and pharmacology and scientists working in the pharmaceutical industries.


 
Last update: 6 Nov 2011