VIRAL HEMORRHAGIC FEVERS AND OTHER EMERGING INFECTIONS, PART B, 78
Part B To order this title, and for more information, click here
Edited By Michael Buchmeier, University of California, Irvine, USA Clarence Peters, University of Texas Medical Branch, Galveston, USA
Audience
Virologists, microbiologists, infectious diseases and public health specialists.
Contents Paramyxoviruses
Nipah Molecular Biology - Rota, Hadler, Bellini
What are the recent advances in understanding the henipivirus genomes?
Modalities to suppress interferon and other innate immune responses? Function of neutralizing antibodies, receptors, etc.
Pathogenesis
of Nipah- Sherif Zaki
Human material and to a lesser extent models have helped remarkably to understand how Nipah virus causes disease.
What are the major findings, their clinical correlations, and most important unresolved questions.
Epidemiology of Nipah - Chua,
Lam
With some time to understand the factors that led to emergence of Nipah in Malaysia, what do we now understand about the timing of
its emergence from bats to pigs to humans and the risk factors and spread in the human population? What is known about the control in
the different foci in Malaysia? How could it have been recognized and controlled earlier?
New, emergent paramyxoviruses - Mackenzie
and Hume Fields
Synthesis of Hendra, Nipah, new Bangladesh agent; plus snake viruses, Mengele, etc. Is this the new fount of emergent
viruses? What changes drove these and will drive future emergences? Why is cross species transfer so easy in these newly recognized
agents when dogma is that there is a great deal of species specificity?
Bunyaviridae: Phleboviruses and Nairoviruses
Epidemiology
of Rift Valley fever, CCHF, and Ngari viruses - Swanpoel
Synthesis of recent molecular with older classical epidemiology to try to understand
the distribution, ebb and flow, and human risk from these viruses. Short discussion of Ngari virus.
Pathogenesis and vaccines
for Rift Valley fever - C.J. Peters
CCHF: Regional epidemiology
Overview - Doug Watts
Russia and Central Asia- author to be determined
Iran - author to be determined
Turkey - author to be determined
Western China - Saijo, Niikura, Kurane
Molecular biology of CCHF
- Clegg
Bunyaviridae: Hantaviruses
Hemorrhagic fever with renal syndrome: Clinical findings, pathogenesis in humans, and viral circulation
in the Balkans - Markotic and Tatiana
Interesting observations in all these areas have been made in Croatia and Slovenia (and probably
other places in former Yugoslavia) and can be synthesized into a nice review (calling on data from outside the region when illustrative).
Hantavirus pulmonary syndrome: a new animal model and it?s lessons for human disease - Jay Hooper and Fred Koster
Flaviruses
Dengue
hemorrhagic fever - Farrar
A balanced review to cover the antibody enhancement vs T cell controversy, discuss new understanding of
viral factors (viremia, emergence of variants with epidemics of DHF). CNS disease as part of the dengue spectrum (role of myocardial
contractility?).
Omsk HF - Netesov and Loktev
Kyasanur Forest disease - author to be determined
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