Description Autoimmune disorders are amongst the most frequently encountered conditions in endocrine practice. The evidence-based approach to therapeutics
and detailed evaluation of the outcome of existing treatment regimens have led to some advances in care delivery. Pragmatic reviews by
leading international experts outline the clinical state of the art in several chapters of this issue of the Endocrinology and Metabolism
Clinics of North America devoted to autoimmune disorders. Topics covered include the following: regulatory T cells as key players in
tolerance and autoimmunity; immunology lessons from monogenic conditions such as AIRE; immunogenetics of T1D and AITD; advances in T1D
therapeutics, including islet cell replacement and salvage; updates on TSHR structure, function, and monoclonal human TSHR antibodies;
animal models of Grave's disease; evidence-based and emerging modalities of treatment of Graves' hyperthyroidism; patient selection and
treatment of thyroid-associated ophthalmopathy; antibodies to steroidogenic tissues: Addison's and POF; diagnosis and management of polyendocrinopathy
syndromes; autoimmune parathyroid disease; and autoimmune hypophysitis.
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