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Edited By John Bilezikian, Columbia University, New York, New York, U.S.A. Lawrence Raisz, University of Connecticut, Farmington, U.S.A. T. John Martin, St. Vincent s Institute of Medical Research, Melbourne, AUSTRALIA
Audience
Academic and medical libraries as well as professionals in bone biology, endocrinology, and osteology.
Contents
Part I
Basic Principles A. Cell Biology
Chapter 1:
Structure, Modeling and Remodeling of Bone / The Size
and Shape of Bone as a Site of Metabolic Bone Activity
Ego Seeman
Chapter 2:
Biomechanics of Bone
Elise Morgan
Chapter 3:
Embryonic
Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation
Andrew Karaplis
Chapter 4:
Mesenchymal
Stem Cells & Osteoblast Lineage
Jane Aubin
Chapter 5:
Transcriptional Control of Osteoblast Differentiation and Function
Thorsten Schinke
Chapter 6:
Wnt Signaling and Bone
Mark Johnson
Chapter 7:
Sclerostin and Bone
Rutger van Bezooijen
Chapter 8:
The Osteocyte
Jenneke
Klein-Nulend
Chapter 9:
Cells of Bone: Osteoplast Generation
Tatsuo Suda
Chapter 10:
Osteoclast Function: Biology and Mechanisms
Kalervo
Vaananen
Chapter 11:
RANK Signaling
Hiroshi Takanayagi
Chapter12:
Regulating Bone Resorption
Roland Baron
Chapter 13:
Apoptosis in
Bone Cells
Stavros Manolagas
Chapter 14:
Skeletal Gene Expression in Nuclear Microenvironments
Gary Stein
B. Biochemistry
Chapter 15:
Type I Collagen: Structure, Synthesis, and Regulation
Benoit de Crombrugghe
Chapter 16:
Collagen Crosslinking & Metabolism
Simon Robins
Chapter 17:
Bone Matrix Proteoglycans & Glycoproteins
Pamela Robey
Chapter 18:
Osteopontin
Masaki Noda
Chapter 19:
Bone
Proteinases
Nicola Partridge
Chapter 20:
Integrins and Other Cell Surface Attachment Molecules of Bone Cells
Michael Horton
Chapter
21:
Intercellular Junctions and Cell-Cell Communication in the Skeletal System
Roberto Civitelli
C. Bone Remodeling and Mineral
Homeostasis
Chapter 22:
Histomorphometric Analysis of Bone Remodeling
David Dempster
Chapter 23:
Phosphorus Homeostasis & Related
Disorders
Marc Drezner
Chapter 24:
Magnesium Homeostasis
Robert Rude
Chapter 25:
Metals in Bone: Aluminum, Boron, Cadmium, Chromium,
Lead, Silicon, & Stro
Felix Bronner
Chapter 26:
Biology of the Extracellular Ca2+-Sensing Receptor
Edward Brown
D. The Hormones
of Bone
Chapter 27:
Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein
John Potts
Chapter 28:
Parathyroid Hormone
- Molecular Biology
Hank Kronenberg
Chapter 29:
Parathyroid Hormone-Receptor Interactions
Mike Rosenblatt
Chapter 30:
Actions of Parathyroid
Hormone on the Vasculature and Cardiovascular System
John Bilezikian
Chapter 31:
The Vascular and Cardiovascular Actions of PTH
John
Bilezikian
Chapter 32:
PTH and PTHrP Actions on Kidney and Bone
Peter Friedman
Chapter 33:
Physiological Actions of Parathyroid Hormone
and PTH-Related Protein
John Wysolmerski
Chapter 34:
Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein
Thomas Clemens
Chapter 35:
Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences
for Genomic and Rapid Biological Responses
Tony Norman
Chapter 36:
Vitamin D Gene Regulation
Sylvia Christakos
Chapter 37:
Photobiology
and Non-Calcemic Actions of Vitamin D
Mike Holick
Chapter 38:
Calcitonin Structure and Molecular Biology of the Calcitonin Receptor
/ Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects
Bob Gagel
Chapter 39:
Amylin and Calcitonin Gene-Related
Peptide
Jill Cornish
E. Other Systemic Hormones That Influence Bone Metabolism
Chapter 40:
Estrogens & Progestins
Russell
Turner
Chapter 41:
The Pharmacology of Selective Estrogen Receptor Modulators
Henry Bryant
Chapter 42:
Mechanisms of Estrogen Action
in Bone
Roberto Pacifici
Chapter 43:
Thyroid Hormone & Bone
Paula Stern
Chapter 44:
Clinical and Basic Aspects of Glucocorticoid Action
in Bone
Barbara Kream
Chapter 45:
Effects of Diabetetes & Insulin on Bone Physiology
Johan Verhaeghe
Chapter 46:
Androgens:Receptor
Expression and Steroid Action in Bone
Kristine Wiren
Chapter 47:
Kinins & Neuro-Osteogenic Factors
Ulf Lerner
Chapter 48:
Regulation
of Bone Remodeling by Central and Peripheral Nervous Signals
Patricia Ducy
F. Local Regulators
Chapter 49:
Insulin-like Growth
Factors and the IGF Binding Proteins: Implications for Bone Biology
Cliff Rosen
Chapter 50:
Platelet-Derived Growth Factor & the Skeleton
Ernesto Canalis
Chapter 51:
Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone
Marja Hurley
Chapter 52:
Vascular Endothelial
Growth Factor and Osteogenic-Angiogenic Coupling
Dwight Towler
Chapter 53:
Transforming Growth Factor-a
Sarah Dallas
Chapter 54:
Bone
Morphogenetic Proteins and the Skeleton
Vicki Rosen
Chapter 55:
Bone Morphogenetic Protein Receptors & Actions
Kohei Miyazono
Chapter
56:
Colony-Stimulating Factor-1
Willy Hofstetter
Chapter 57:
Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10,
IL-4, the LIF/IL-6 Family, and Additional Cytokines
Mark Horowitz
Chapter 58:
Prostaglandins & Bone Metabolism
Carol Pilbeam
Part
II
Molecular Mechanisms of Metabolic Bone Disease
Chapter 59:
Skeletal Effects of Nitric Oxide: Novel Agent for Osteoporosis
Sunil Wimalawansa
Chapter 60:
Molecular Basis of PTH Overexpression
Andy Arnold
Chapter 61:
Familial Benign Hypocalciuric Hypercalcemia
and Neonatal Primary Hyperparathyroidism
Ghada EI-Hajj Fuleihan
Chapter 62:
Multiple Endocrine Neoplasia Type I
Maria Luisa Brandi
Chapter 63:
Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy
David Goltzman
Chapter
64:
Local Factors in Skeletal Malignancy
Greg Mundy
Chapter 65:
Genetic Regulation of the Parathyroid Gland Development
Raj Thakker
Chapter 66:
Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP
Receptor Mutations
Harald Jueppner
Chapter 67:
Diseases Resulting from Defects in the G Protein Gs
Lee Weinstein
Chapter 68:
Renal
Osteodystrophy – Pathogenic Mechanisms and Therapeutic Options
Bill Goodman
Chapter 69:
Osteogenesis Imperfecta
David Rowe
Chapter
70:
Hereditary Deficiencies in Vitamin D Action
Uri Liberman
Chapter 71:
Oncogenic Osteomalacia
Suzanne Jan de Beur
Chapter 72:
Osteopetrosis
Lyndon Key
Chapter 73:
Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans
Michael Whyte
Chapter 74:
Paget's
Disease of Bone
Fred Singer
Chapter 75:
Genetic Determinants of Bone Mass and Osteoporotic Fracture
Stuart Ralston
Chapter 76:
Pathophysiology
of Osteoporosis
Bilezikian, Raisz, Martin
Chapter 77:
Evaluation of Risk for Osteoporosis Fracture
Stuart Silverman
Part III
Pharmacological Mechanisms of Therapeutics
Chapter 78:
Parathyroid Hormone
Dave Hanley
Chapter 79:
Calcium
Robert Heaney
Chapter 80:
Drugs Acting on the Calcium Receptor Calcimimetics and Calcilytics
Edward Nemeth
Chapter 81:
Bisphosphonates: Mechanisms
of Action
Graham Russell
Chapter 82:
The Pharmacology of Estrogens in Osteoporosis
Robert Lindsay
Chapter 83:
Vitamin D & Analogs
Glenville
Jones
Chapter 84:
Estrogen Effects on Bone in the Male Skeleton
Luigi Gennari
Chapter 85:
Mechanisms of Exercise Effects on Bone Quantity
and Quality
Clint Rubin
Part IV
Methods in Bone Research
Chapter 86:
Application of Transgenic Mice to Problems of
Skeletal Bone
Stephen Clark
Chapter 87:
Biochemical Markers of Bone Metabolism
Markus Seibel
Chapter 88:
Methods and Clinical Issues
in Bone Densitometry
Glen Blake
Chapter 89:
Controversial Issues in Bone Densitometry
Paul Miller
Chapter 90:
Macro and Micro Imaging
of Bone Architecture
Klaus Engelke, Sven Prevrhal, and Harry K. Genant
Volumes
1-2: Principles of Bone Biology, Two-Volume Set, 1-2
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