Audience
Immunologists, rheumatologists, endocrinologists, and neuroendocrinologists.
Contents I. History
The history of Neuroimmune Biology:
II. Cytokines and in the brain;
A.Cytokines, their receptors and signal transduction
in the brain;
Cytokine Receptors in the Brain;
Interleukin-1 and Corticotropin Releasing Factor Receptors in the Hypothalamic-Pituitary-Adrenal
Axis;
Brain interleukin-1a expression and action in the absence of neuropathology;
Interleukin 1a signal transduction via the sphingomyelin
pathway in brain cells;
Blood-brain barrier transport of cytokines;
B. Cytokines in brain physiology
Cytokines in synaptic function;
Interleukin-2 as a Neuroregulatory Cytokine;
Cytokines and Extracellular Matrix Remodeling in the Central Nervous System;
Acidic fibroblast
growth factor, a satiety substance, variegated physiological significance;
Cytokines and Sleep;
C. Chemokines in the brain;
Chemokines,
their receptors and significance in brain function;
IV. Immune response in the brain;
Immune and inflammatory responses in the CNS:
modulation by astrocytes;
Immune Response in the Brain: Glial Response and Cytokine Production;
V. Cytokines in pathophysiological
brain responses;
A. Brain-immune interaction
Lymphocytes and adrenergic sympathetic nerve system: the role of cytokines;
Cytokines in
Neural Signaling to the Brain;
Interleukin-2 gene expression in CNS cells after stress and antigen application;
Sex hormones and cytokines
in CNS pathology and repair;
Involvement of brain cytokines in stress-induced immunosuppression;
Neuroprotective Effects of Inflammation
in the Nerves System;
VI. Disease;
Brain Response to Endotoxin;
Cytokines in Demyelinating Disease;
The Cytokines and Depression Hypothesis:
An Evaluation;
Clinical Relevance: Cytokines in Alzheimer?s Disease;
VII. Cytokines and behaviour;
Cytokines and immune-related behaviors;
The production and effects of cytokines depend on brain lateralization;
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