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Edited By Robert Marcus, Emeritus, Department of Medicine, Stanford University School of Medicine, Stanford, California, U.S.A. David Feldman, Stanford University School of Medicine, Stanford, California, USA Dorothy Nelson, Wayne State University, Detroit, MI, U.S.A. Clifford Rosen, The Jackson Laboratory, Bar Harbor, Maine, U.S.A.
Description Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by
renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers,
and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis
and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition
covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic
fractures in the U.S. reach up to $18 billion each year.
Audience
Academic and medical libraries as well as professionals in bone biology, endocrinology, osteology, neuroendocrinology; drug companies developing osteoporosis medications
Contents
Introduction
The Bone Organ System: Form and Function
The Nature of Osteoporosis
The Economics of Osteoporosis
Reflections
on Osteoporosis
Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the
Understanding of Osteoporosis
Basic
Science/Bone Biology
Osteoblast Biology
Osteoclast Biology
Osteocytes
The Regulatory Role of Matrix Proteins in Mineralization
of Bone
Development of the Skeleton
Mouse Genetics as a Tool to Study Bone Development and Physiology
Parathyroid Hormone and Parathyroid
Hormone-Related Protein
Vitamin D: Biology, Action, and Clinical Implications
Regulation of Bone Cell Function by Estrogens
Androgens
and Skeletal Biology: Basic Mechanisms
Phosphatonins
Wnt Signaling in Bone
Cytokines and Bone Remodeling
Skeletal Growth Factors
Intercellular
Communication During Bone Remodeling
Structural and Biomechanics
Skeletal Development: Mechanical Consequences of Growth,
Aging and Disease
Inhibition of Osteoporosis by Biophysical Intervention
Biomechanics of Age-Related Fractures
Bone Quality
Epidemiology & Risk Factors
Epidemiologic Methods in Studies of Osteoporosis
Race, Ethnicity and Osteoporosis
The Study of Osteoporotic Fractures
(SOF): Major Findings and Contributions
Bone Mineral Acquisition in Utero and During Infancy and Childhood
Bone Acquisition in Adolescence
Genetic Determinants of Osteoporosis
Nutrition and Risk for Osteoporosis
Physical Activity in Prevention
of Osteoporosis and Associated Fractures
Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis
Non-Skeletal Risk Factors for Osteoporosis and Fractures
Falls as Risk Factors for Fracture
Assessment
of Fracture Risk
Outcomes of Osteoporotic Fractures
Pathophysiology
Local and Systemic Factors
in the Pathogenesis of Osteoporosis
Animal Models for Osteoporosis
Estrogen, Bone Homeostasis and Osteoporosis
Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss
Osteoporosis in Men: Epidemiology, Pathophysiology,
and Clinical Characterization
Osteoporosis in Childhood and Adolescence
Glucocorticoid-Induced Osteoporosis
Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach
Mechanisms of Immobilization-induced Bone
Loss
Leptin-Dependent Regulation of Bone Mass
Thyroid Hormone and the Skeleton
Osteoporosis in Gastrointestinal,
Pancreatic, and Hepatic Disease
The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis
Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis
Osteoporosis Associated
with Illnesses and Medications
Transplantation Osteoporosis
Osteoporosis Associated with Cancer Therapy
Osteoporosis Associated with Pregnancy
Osteoporosis Associated with Rheumatologic Disease
Oral Bone Loss and Systemic
Osteopenia: Potential Treatment and Risks
Localized Osteoporosis
Evaluation and Management
Evaluation
of the Patient with Osteoporosis or at Risk for Osteoporosis
Who Should be Screened: Who Should be Treated?
Radiology
of Osteoporosis
Clinical Use of Bone Densitometry
Biochemical Markers of Bone Turnover in Osteoporosis
The Conundrum
of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis
An Orthopedic Perspective of Osteoporosis
Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs
Pharmacology and Therapeutics
Design Considerations for Clinical Investigations of Osteoporosis
Regulatory Considerations for the Design and Conduct of
Osteoporosis Registration Trials
Evidence-Based Osteoporosis Care
The Role of Calcium in the Treatment of Osteoporosis
Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis
Estrogen Therapy: Prevention and Treatment
of Osteoporosis
Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and Phytoestrogens
Bisphosphonates: Pharmacology
and Use in the Treatment of Osteoporosis
Calcitonin in Osteoporosis
Strontium Therapy for Osteoporosis
Androgens
Treatment with PTH Peptides
Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations
in the Management of Osteoporosis
New approaches to Osteoporosis Therapeutics
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