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The Design and Manufacture of Medicines
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Third Edition
By
Michael Aulton, BPharm, PhD, FAAPS, MRPharmS, Professor of Pharmaceutical Technology, School of Pharmacy, De Montfort University, Leicester, UK
Description
Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific
and technological aspects of the design and manufacture of dosage forms for medicines. An understanding of pharmaceutics is therefore
vital to all pharmacists and pharmaceutical scientists who are involved in converting a drug or a potential drug into a medicine that
can be delivered safely, efficiently and conveniently to the patient.
Professor Aulton's Pharmaceutics has become established
as the clearest, most comprehensive textbook on this subject. The book provides pharmacy and pharmaceutical science students with the
latest information on all aspects of pharmaceutics.
Contents
What is ?pharmaceutics'?
Design of dosage forms
PART ONE: SCIENTIFIC PRINCIPLES OF DOSAGE FORM DESIGN
*Dissolution and solubility
*Properties of solutions
*Rheology
*Surface and interfacial phenomena
*Disperse systems
*Kinetics of product stability
PART TWO: PARTICLE SCIENCE AND POWDER TECHNOLOGY
*Solid-state properties
*Particle size analysis
*Particle size reduction
*Particle size separation
*Mixing
*Powder flow.
PART
THREE: PHARMACEUTICAL MICROBIOLOGY AND STERILIZATION
*Fundamentals of microbiology
*Pharmaceutical applications
of microbiological techniques
*Action of physical and chemical agents on microorganisms
*Principles of sterilization
*Sterilization
in practice
PART FOUR: BIOPHARMACEUTICAL PRINCIPLES OF DRUG DELIVERY
*Introduction to biopharmaceutics
*Gastrointestinal tract – physiology and drug absorption
*Bioavailability – physicochemical and dosage form factors
*Assessment
of biopharmaceutical properties
*Dosage regimens
PART FIVE: DOSAGE FORM DESIGN AND MANUFACTURE
*Pharmaceutical
preformulation
*Solutions
*Clarification
*Suspensions and emulsions
*Powders and granules
*Granulation
*Drying
*Tablets and compaction
*Modified-release peroral dosage forms
*Coating of tablets and multiparticulates
*Hard gelatin capsules
*Soft gelatin capsules
*Pulmonary drug delivery
*Nasal drug delivery
*Transdermal
drug delivery
*Wound dressings
*Rectal and vaginal drug delivery
*Delivery of pharmaceutical proteins
*Packs and
packaging
*Microbial contamination, spoilage and preservation of medicines
*Product stability and stability testing
*Pharmaceutical
plant design
*Heat transfer and the properties and use of steam
| Bibliographic details |
Paperback, 736 pages, publication date: SEP-2007
ISBN-13: 978-0-443-10108-3
ISBN-10: 0-443-10108-6
Imprint: CHURCHILL LIVINGSTONE
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049/438
Last update: 25 Nov 2009
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