Text with Continually Updated Online Reference To order this title, and for more information, click here Eighteenth Edition
By Robert Kliegman, MD, Professor and Chair, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI Richard Behrman, MD, Executive Chair, Pediatric Education Steering Committee, Federation of Pediatric Organizations, Menlo Park, CA; Clinical Professor
of Pediatrics, Stanford University and the University of California, San Francisco, CA; George Washington University, Washington, DC Hal Jenson, MD, Chair, Department of Pediatrics, Director, Center for Pediatric Research, and Senior Vice-President for Academic Affairs, Eastern
Virginia Medical School and Children's Hospital of the King's Daughters, Norfolk, VA Bonita Stanton, MD, Schotanus Professor and Chair, Department of Pediatrics, Wayne State University, Detroit, MI, USA
Description For nearly three quarters of a century, Nelson Textbook of Pediatrics has been the world's most trusted resource for best approaches to
pediatric care. Now in full color for easier referencing, this New Edition continues the tradition, incorporating a wealth of exciting
updates and changes?ensuring you have access to today's authoritative knowledge to best diagnose and treat every pediatric patient you
see. Whether you're treating patients in the office or in the hospital, or preparing for the boards, Nelson Textbook of Pediatrics, 18th
Edition is your comprehensive guide to providing the best possible care.
Contents
Part I: The Field of Pediatrics
1 Overview of Pediatrics
2 Quality and Safety in Healthcare for Children
3 Ethics in Pediatric
Care
4 Cultural Issues in Pediatric Care
5 Maximizing Children?s Health: Screening, Anticipatory Guidance, and Counseling
Part
II: Growth, Development, and Behavior
6 Overview and Assessment of Variability
6.1 Assessment of Fetal
Growth and Development
7 The Newborn
8 The First Year
9 The Second Year
10 Preschool Years
11 Middle Childhood
12 Adolescence
13 Sexual
Behavior
13.1 The Development of Sexual Behavior
13.2 Gender Identity Disorder (GID)
13.3 Adolescent Homosexuality
14 Assessment of
Growth
15 Developmental Screening and Surveillance
16 Child Care: How Pediatricians Can Support Children and Famillies
17 Separation,
Loss, and Bereavement
18 Sleep Medicine
Part III: Child and Adolescent Psychology
19 Assessment
and Interviewing
20 Psychological Treatment of Children and Adolescents
20.1 Illness and Death
20.2 Psychopharmacology
20.3 Psychotherapy
20.4 Psychiatric Hospitalization
21 Psychosomatic Illness
22 Vegetative Disorders
22.1 Rumination Disorders
22.2 Pica
22.3 Enuresis (Bedwetting)
22.4 Encopresis
23 Habit and Tic Disorders
24 Anxiety Disorders
25 Mood Disorders
25.1 Major Depression
25.2 Dysthymic Disorder
25.3
Bipolar Disorder
26 Suicide and Attempted Suicide
27 Anorexia Nervosa, Bulimia, and Binge Eating
28 Disruptive Behavioral Disorders
29 Pervasive Developmental Disorders and Childhood Psychosis
29.1 Autistic Disorder
29.2 Asperger?s Disorder
29.3 Childhood Disintegrative
Disorder
29.4 Rett's Disorder
29.5 Childhood Schizophrenia
29.6 Acute Phobic Hallucinations
30 Patterns of Development and Function in
the School-Aged Child
31 Attention Deficit Hyperactivity Disorder
32 Specific Reading Disability
32.1 Language Development and Communication
Disorders
PART IV: Children with Special Needs
33 Adoption
34 Foster Care
35 Impact of Violence on Children
35.1
School Violence and Bullying
35.2 Effect of War on Children
36 Abuse and Neglect of Children
36.1 Sexual Abuse
36.2 Munchausen Syndrome
by Proxy
36.3 Parental Styles
37 Failure to Thrive
38 Developmental Disabilities and Chronic Illness
38.1 Mental Retardation (Intellectual
Disability)
39 Organ Transplantation
40 Pediatric Palliative Care: The Care of Children with Life-Limiting Illness
40.1 Grief and Bereavement
Part V: Nutrition
41 Nutritional Requirements
42 The Feeding of Infants and Children
43 Food Insecurity, Hunger, and Undernutrition
44 Overweight and Obesity
45 Vitamin A Deficiency and Excess
46 Vitamin B Complex Deficiency and Excess
46.1 Thiamin (Vitamin B-1)
46.2
Riboflavin (Vitamin B-2)
46.3 Niacin
46.4 Vitamin B-6 (Pyridoxine)
46.5 Biotin
46.6 Folate
46.7 Vitamin B-12 (Cobalamin)
47 Vitamin C
Deficiency (Ascorbic Acid)
48 Rickets and Hypervitaminosis D
49 Vitamin E Deficiency
50 Vitamin K Deficiency
51 Micronutrient Deficiency
Part VI: The Pathophysiology of Body Fluids and Fluid Therapy
52 Electrolyte and Acid-Base Disorders
52.1 Composition of Body
Fluids
52.2 Regulation of Osmolality and Volume
52.3 Sodium
52.4 Potassium
52.5 Magnesium
52.6 Phosphorus
52.7 Acid-Base Balance
53 Maintenance
and Replacement Therapy
54 Deficit Therapy
55 Fluids and Electrolyte Treatment of Specific Disorders
55.1 Acute Diarrhea and Oral Rehydration
55.2 Diarrhea in Chronically Malnourished Children
55.3 Pyloric Stenosis
55.4 Perioperative Fluids
Part VII: Pediatric Drug
Therapy
56 Pharmacogenetics, Pharmacogenomics, and Pharmacoproteins
57 Principles of Drug Therapy
58 Poisonings
59 Herbal Medicines
Part VIII: Critical Care Medicine
60 Evaluation of the Sick Child in the Office and Clinic
61 Injury Control
62 Emergency
Medical Services for Children
63 Interfacility Transfer of the Critically Ill Infant and Child
64 Monitoring Techniques for the Critically
Ill Infant and Child
65 Scoring Systems and Predictors of Mortality
66 Pediatric Emergencies and Resuscitation
67 Neurologic Emergencies
and Stabilization
67.1 Brain Death
68 Shock
69 Respiratory Distress and Failure
70 Mechanical Ventilation
70.1 Chronic Mechanical Ventilation
71 Acute Care of the Multiple Trauma Victim
72 Nutritional Stabilization
73 Drowning
74 Burn injuries
75 Cold Injuries
76 Anesthesia
and Perioperative Care
77 Pediatric Pain Management
Part IX: Human Genetics
78 The Genetic Approach in Pediatric Medicine
79 The Human Genome
80 Patterns of Genetic Transmission
81 Cytogenetics
82 Genetics of Common Disorders: Diagnosis and Management
83
Integration of Genetics into Pediatric Practice
Part X: Metabolic Diseases
84 An Approach to Inborn Errors of Metabolism
85 Defects in Metabolism of Amino Acids
85.1 Phenylalanine
85.2 Tyrosine
85.3 Methionine
85.4 Cysteine/Cystine
85.5 Tryptophan
85.6
Valine, Leucine, Isoleucine, and Related Organic Acidemias
85.7 Glycine
85.8 Serine
85.9 Proline
85.1-0 Glutamic Acid
85.11 Urea Cycle
and Hyperammonemia (Arginine, Citrulline, Ornithine)
85.12 Histidine
85.13 Lysine
85.14 Aspartic Acid (Canavan Disease)
86 Defects in
Metabolism of Lipids
86.1 Disorders of Mitochondrial Fatty Acid β-Oxidation
86.2 Disorders of Very Long Chain Fatty Acids
86.3 Disorders
of Lipoprotein Metabolism and Transport: Epidemiology of Blood Lipids and Cardiovascular Disease
86.4 Lipidoses
86.5 Mucolipidoses
87
Defects in Metabolism of Carbohydrates
87.1 Glycogen Storage Diseases
87.2 Defects in Galactose Metabolism
87.3 Defects in Fructose Metabolism
87.4 Defects in Intermediary Carbohydrate Metabolism Associated with Lactic Acidosis
87.5 Defects in Pentose Metabolism
87.6 Disorders
of Glycoprotein Degradation and Structure
88 Mucopolysaccharidoses
89 Disorders of Purine and Pyrimidine Metabolism
90 Progeria
91 The
Porphyrias
92 Hypoglycemia
Part XI: Perinatal and Neonatal Medicine
93 Overview of Mortality
and Morbidity
94 The Newborn Infant
94.1 History in Neonatal Pediatrics
94.2 Physical Examination of the Newborn Infant
94.3 Routine
Delivery Room Care
94.4 Nursery Care
94.5 Parent-Infant Bonding
95 High-Risk Pregnancies
96 The Fetus
96.1 Fetal Growth and Maturity
96.2 Fetal Distress
96.3 Maternal Disease and the Fetus
96.4 Maternal Medication and Toxin Exposure and the Fetus
96.5 Teratogens
96.6
Radiation
96.7 Intrauterine Diagnosis of Fetal Disease
96.8 Treatment and Prevention of Fetal Disease
97 The High-Risk Infant
97.1 Multiple
Gestation Pregnancies
97.2 Prematurity and Intrauterine Growth Retardation
97.3 Post-Term Infants
97.4 Large for Gestational Age
97.5
Infant Transport
98 Clinical Manifestations of Diseases in the Newborn Period
99 Nervous System Disorders
99.1 The Cranium
99.2 Traumatic,
Epidural, Subdural, and Subarachnoid Hemorrhage
99.3 Intracranial-Intraventricular Hemorrhage and Periventricular Leukomalacia
99.4 Brain
Injury from Inflammation, Infection, and Medications
99.5 Hypoxia-Ischemia
99.6 Spine and Spinal Cord
99.7 Peripheral Nerve Injuries
100 Delivery Room Emergencies
101 Respiratory Tract Disorders
101.1 Transition to Pulmonary Respiration
101.2 Apnea
101.3 Congenital
Central Hypoventilation Syndrome
101.4 Respiratory Distress Syndrome (Hyaline Membrane Disease)
101.5 Transient Tachypnea of the Newborn
101.6 Aspiration of Foreign Material (Fetal Aspiration Syndrome, Aspiration Pneumonia)
101.7 Meconium Aspiration
101.8 Persistent Pulmonary
Hypertension of the Newborn (Persistent Fetal Circulation)
101.9 Diaphragmatic Hernia
101.10
Foramen of Morgagni Hernia
101.11 Paraesophageal Hernia
101.12 Eventration
101.13 Extrapulmonary Extravasation of Air (Pneumothorax,
Pneumomediastinum, Pulmonary Interstitial Emphysema)
101.14 Pulmonary Hemorrhage
102 Digestive System Disorders
102.1 Meconium Ileus
in Cystic Fibrosis
102.2 Neonatal Necrotizing Enterocolitis (NEC)
102.3 Jaundice and Hyperbilirubinemia in the Newborn
102.4 Kernicterus
103 Blood Disorders
103.1 Anemia in the Newborn Infant
103.2 Hemolytic Disease of the Newborn (Erythroblastosis Fetalis)
103.3 Plethora
in the Newborn Infant (Polycythemia)
103.4 Hemorrhage in the Newborn Infant
104 Genitourinary System
105 The Umbilicus
106 Metabolic
Disturbances
106.1 Maternal Selective Serotonin Reuptake Inhibitors and Neonatal Behavioral Syndromes
106.2 Fetal Alcohol Syndrome
107
The Endocrine System
107.1 Infants of Diabetic Mothers
107.2 Hypoglycemia
108 Dysmorphology
109 Infections of the Neonatal Infant
109.1
Pathogenesis and Epidemiology
109.2 Modes of Transmission and Pathogenesis
109.3 Immunity
109.4 Etiology of Fetal and Neonatal Infection
109.5 Epidemiology of Early- and Late-Onset Neonatal Infections
109.6 Clinical Manifestations of Transplacental Intrauterine Infections
109.7 Diagnosis
109.8 Treatment
109.9 Complications and Prognosis
109.1'0 Prevention
Part XII: Adolescent Medicine
110 The Epidemiology of Adolescent Health Problems
111 Delivery of Health Care to Adolescents
111.1 Legal Issues
111.2 Screening Procedures
111.3 Health Enhancement
112 Violent Behavior
113 Substance Abuse
113.1 Alcohol
113.2 Tobacco
113.3 Marijuana
113.4 Volatile Inhalants
113.5 Hallucinogens
113.6 Cocaine
113.7 Amphetamines
113.8 Opiates
113.9 Anabolic Steroids
114 The Breast
115 Menstrual Problems
115.1
Amenorrhea
115.2 Abnormal Uterine Bleeding
115.3 Dysmenorrhea
115.4 Premenstrual Syndrome
116 Contraception
116.1 Barrier Methods
116.2
Spermicides
116.3 Combination Methods
116.4 Hormonal Methods
116.5 Emergency Contraception
116.6 Intrauterine Devices
117 Adolescent
Pregnancy
118 Adolescent Rape
119 Sexually Transmitted Infections
120 Chronic Fatigue Syndrome
Part XIII: Immunology
Section 1: Evaluation of the Immune Systems
121 Evaluation of Suspected ImmunodeficiencySection 2: The T-, B-, and NK-Cell
Systems
122 T Lymphocytes, B Lymphocytes, and Natural Killer Cells
123 Primary Defects of Antibody
Production
123.1 Treatment of B-Cell Defects
124 Primary Defects of Cellular Immunity
125 Primary Combined Antibody and Cellular Immunodeficiencies
125.1 Severe Combined Immunodeficiency (SCID)
125.2 Combined Immunodeficiency (CID)
125.3 Defects of Innate Immunity
125.4 Treatment
of Cellular or Combined Immunodeficiency
125.5 Immune Dysregulation with Autoimmunity or LymphoproliferationSection 3: The Phagocytic
System
126 Neutrophils
127 Monocytes and Macrophages and Dendritic Cells
128 Eosinophils
129 Disorders of Phagocyte Function
130 Leukopenia
131 Leukocytosis Section 4: The Complement System
132 The Complement System
133 Disorders of the Complement System
133.1 Evaluation
of the Complement System
133.2 Genetic Deficiencies of Complement Components
133.3 Deficiencies of Plasma, Membrane, or Serosal Complement
Control Proteins
133.4 Secondary Disorders of Complement
133.5 Treatment of Complement DisordersSection 5:
134 Principles and
Clinical Indications
135 HSCT from Alternative Sources and Donors
136 Graft vs Host Disease (GVHD) and Rejection
137 Infectious Complications
of HSCT
138 Late Effects of HSCT
Part XIV: Allergy
139 Allergy and the Immunologic Basis of Atopic Disease
140 Diagnosis
of Allergic Disease
141 Principles of Treatment of Allergic Disease
142 Allergic Rhinitis
143 Childhood Asthma
144 Atopic Dermatitis
(Atopic Eczema)
145 Insect Allergy
146 Ocular Allergies
147 Urticaria and Angioedema (Hives)
148 Anaphylaxis
149 Serum Sickness
150
Adverse Reactions to Foods
151 Adverse Reactions to Drugs
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