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| EXTRACELLULAR MATRIX AND THE LIVER
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Approach to Gene Therapy
To order this title, and for more information, click here
Edited By
Isao Okazaki, Tokai University School of Medicine, Tokyo, Japan
Yosifumi Ninomiya, Okayama University Medical School, Japan
Tanikawa Kyuichi, Kurume University School of Medicine, Japan
Scott Friedman, Mount Sinai School of Medicine, New York, NY, USA
Description
Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses
new strategies
for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy
approaches.
The chapters are divided into
six sections as follows:
* Basic Science of Extracellular Matrix
* Cells Responsible for Extracellular Matrix Production
* Activation
Mechanism of Hepatic Cells and Signal Transduction
* Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors
* Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases
* New Strategies for the treatment of Liver Cirrhosis
Audience
Hepatologists, molecular geneticists, gastroenterologists, oncologists, and hematologists.
Contents
New Insights into the Extracellular Matrix.
Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors.
Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates.
Functions
of Proteoglycan/Glycosaminoglycan in Liver; SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular
and Connective Tissue Biology.
Cells Responsible for ECM Production in the Liver. Different Hepatic Cell Populations of the Fibroblast
Lineage with Fibrogenic Potential.
Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair.
Molecular Mechanism of Stellate
Cell Activation and ECM Remodeling.
Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype.
Knockout Mice of Matrix Metalloproteinase Genes. Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis.
| Bibliographic details |
Hardbound, 512 pages, publication date: FEB-2003
ISBN-13: 978-0-12-525251-5
ISBN-10: 0-12-525251-X
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
USD 200
GBP 121
EUR 142.95
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Last update: 7 Sep 2009
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