Editor-in-Chief:
Emilio Benfenati, Laboratory of Environmental Chem. and Toxicology, Mario Negri Institute, Miliano, Italy
Description
Quantitative Structure-Activity Relationship (QSAR) for Pesticide Regulatory Purposes stems from the experience of the
EC funded project DEMETRA. This project combined institutes involved in the regulatory process of pesticides, industries of the sector
and scientists to develop and offer original software for the prediction of ecotoxicity of pesticides. Then to be used within the dossier
preparation for pesticide registration. The basis of this book is more than three-years of research activities, discussions, studies
and successful models. This experience represents a useful example not only for the case of pesticides, but also for the prediction of
ecotoxicity and toxicity in general.
QSAR is used to link a given property of a chemical compound with some features related to
its structure. The theoretical toxicological, chemical and information technology aspects will be treated considering the regulatory
issues. Innovative hybrid systems will be described, for the toxicity prediction of pesticides and related compounds, directly useful
for pesticide evaluation within the Dossier preparation for pesticide registration. Five endpoints will also be discussed, addressing
issues as standardisation, verification, validation, accessibility, reproducibility.
The driving force for
Quantitative
Structure-Activity Relationship (QSAR) for Pesticide Regulatory Purposes is that all the issues of concern for end-users are
analysed, discussed and solutions proposed further. An innovative feature is that, in order to offer powerful QSAR models, the book discusses
and reports on integrated QSAR models, combined into a unique hybrid system.
Audience:
For regulators of chemicals, chemical industries, scientists in QSAR field; IT, and toxicology, consumer and animal protection associations
