Description The different LC-MS techniques available today were developed to suit specific analytical needs and the application range covered by each
one is wide, but still limited. GC amenable compounds can be all analyzed with a single GC-MS system whereas HPLC applications call for
specific LC-MS instrumental arrangements. ESI, APCI, APPI, and EI are ionization techniques that can be combined with different analyzers,
in single or tandem configuration, to create the ultimate system for a certain application. Once approaching LC-MS for a specific need,
the fast technical evolution and the variegated commercial offer can induce confusion in the potential user.
The role of this book is
to enlighten the state-of-the-art of LC-MS evolution through a series of contributions written by the people that brought major, recent
innovations in the field. Each chapter will take into consideration the novelties, the advantages and the possible applications covered
by a particular technical solution. The book will also include new analytical methods that can provide benefits using the most recent
innovations in LC-MS plus a certain number of key applications.
Audience
Researchers, Practitioners, Consultants in Analytical Chemistry using LC-MS. (Industry examples: pharmaceuticals, chemical industry, environmental
testing labs, food testing labs, forensics, proteomics)
Contents
1. Basic aspects of electrospray ionization (L. Molin, P. Traldi)
1.1 The taylor cone
1.2 Fate of sprayed
droplets
1.3 Ions formation from charged droplets
1.4 Some further considerations
2. Atmospheric pressure
chemical ionization (APCI): new avenues for an old friend (A. Raffaelli)
2.1 Introduction
2.2 Principles and
apparatus
2.3 Applications
3. Electron ionization in LC?MS: a technical overview of the direct EI interface (A.
Cappiello, P. Palma)
4. Electron ionization LC?MS with supersonic molecular beams (O. Granot, A. Amirav)
4.1
Introduction
4.2 Experimental – liquid sampling EI?MS with SMB
4.3 Results – Cold EI mass spectra
4.4 Results – Selected applications
4.5 Discussion and potential advantages
5. A case for congruent multiple ionization modes
in atmospheric pressure ionization mass spectrometry (M.P. Balogh)
5.1 Introduction
5.2 Atmospheric pressure ionization:
electrospray
5.3 Atmospheric pressure ionization: chemical ionization
5.4 Atmospheric pressure ionization: photoionization
5.5 Combining ionization mechanisms
5.6 Developing reproducible mechanism boundaries
5.7 True combined mechanism
designs
5.8 Development of ESCi® multimode ionization
5.9 Applications of multimode ionization
5.10 Developments
in progress
6. Atmospheric pressure laser ionization (APLI)
(O.J. Schmitz, T. Benter)
6.1 Motivation
6.2 Principles of laser ionization
6.3 Spectroscopic considerations
6.4 From jet-REMPI to APLI
6.5 Coupling
stages for APLI MS and experimental results
6.6 Conclusions and outlook
7. LC?ICP-MS – a primary tool for elemental
speciation studies? (K. Wrobel et al.)
7.1 Introduction: target elements and samples in
speciation analysis
7.2 Inductively coupled plasma mass spectrometry (ICP-MS) as element-specific detector
7.3 Liquid chromatographic techniques
for species separation
7.4 Coupling ICP-MS to liquid chromatography
7.5 Element speciation by LC-ICP-MS in the real-world
samples
7.6 Approaching a higher reliability of speciation results
7.7 Conclusions
8. HPCL?chip/MS: a
new approach to nano-LC/MS (T.A. van de Goor)
8.1 Introduction
8.2 Micro fabrication of HPLC-CHIP devices
8.3 Analytical performance of HPLC-CHIP/MS versus nano-LC/MS [10]
8.4 Applications of HPLC-CHIP/MS
8.5 Future directions
8.6 Conclusion
9. Matrix effect, signal suppression and enhancement in LC?ESI?MS (L. Tonidandel, R. Seraglia)
10. Differential mobility spectrometry (FAIMS): a powerful tool for rapid gas phase ion separation and detection
(R.A. Miller et al.)
10.1 Introduction and history
10.2 Principle of operation overview
10.3 How
it works: fundamentals of the ion separation method
10.4 Physical implementation: planar versus cylindrical ion filter geometries
10.5 The importance of ionization: fundamentals of atmospheric pressure ion formation and ion chemistry
10.6 Applications
of DMS
10.7 Conclusion
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