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Second Edition
Edited By
M.E. Gershwin, University of California, Clinical Division of Rheumatology, School of Medicine, Davis, CA, USA
Pier-Luigi Meroni, Department of Immunology, University of Milan, Italy
Y. Shoenfeld, Department of Medicine 'B', The Research Center of Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Description
Autoimmune diseases are characterized by the occurrence of antibodies reacting with self constituents of the body. This exciting new reference
is an exhaustive review of the main autoantibodies identified up to now, with particular emphasis on those autoantibodies that display
a clinical value. Each chapter is focussed on a single family of autoantibodies by reviewing their historical notes, definition, origin
and source(s) of the antigen(s) recognized, genetic associations, pathogenic mechanisms that are mediated, method(s) of detection and
clinical utility (disease prevalence/association, diagnostic value, sensitivity and specificity, prognostic value). An ideal reference
for anyone involved in the field of autoimmune diseases.
Audience
Physicians and students in Internal Medicine, Rheumatology, Clinical Immunology, Hematology, Endocrinology, Gastroenterology, Neurology,
Nephrology, and Dermatology. Also of interest to those working in companies involved in selling
diagnostic assays for autoimmune disorders.
Contents
PREFACE
FOREWORD
V Autoantibodies: History and Horizons
INTRODUCTION: AUTOANTIBODIES-UNIQUE CHARACTERISTICS
What is an autoantibody?
Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity
Molecular Mimicry
Affinity and Avidity
of Autoantibodies
Pathogenic Mechanisms and Clinical Relevance of Autoantibodies
Native Autoantigens Versus Recombinant Autoantigens
Redox-Reactive Autoantibodies
Predictive Autoantibodies
Autoantibody Subclasses
Idiotypes and Anti-idiotypes
Novel Diagnostic Methods
for Autoantibody Detection
ALLERGIC DISEASE AUTOANTIBODIES
Human IgE Specific Autoantibodies and Autoantibodies to IgE
Receptors
ANTINEUTROPHIL ANTIBODIES
Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase
Novel
Thoughts on Antineutrophil Cytoplasmic Autoantibodies
Neutrophil-Specific Antinuclear and Anti-Cytoplasmic Antibodies in Chronic Inflammatory
Diseases
Antineutrophil Cytoplasmatic Autoantibodies with Specificity to Proteinase 3
ANTINUCLEAR ANTIBODIES
Antinuclear
Antibodies: General Introduction
Anti-nucleolar Antibodies
Anti-Chromatin (Nucleosome) Autoantibodies
Centromere Autoantibodies
dsDNA
Autoantibodies
Histone Autoantibodies
Ku and Ki Autoantibodies
Neuronal Nuclear Autoantibodies, Type 1 (Hu)
Nuclear Envelope Protein
Autoantibodies/Anti-laminin Autoantibodies
Anti-nucleosome Autoantibodies
Proliferating Cell Nuclear Antigen Autoantibodies
Anti-RA-33
Antibodies (Antibodies to the Heterogeneous Nuclear Ribonucleoprotein A2
Anti-Ribosomal P Antibodies
SS-A (Ro) Autoantibodies
Topoisomerase-I
(Sci-70) Autoantibodies
SS-B (La) Autoantibodies
Anti-RNA Polymerase III Antibodies
AUTOANTIBODIES TO BIOLOGIC FACTORS/STRUCTURES
GW Bodies, P Bodies and Components of the miRNA Pathway
Golgi Complex and Endosome Antibodies
p53 Autoantibodies
Human Antiganglioside
Autoantibodies
Human Anti-? -Galactosyl Antibodies
Autoantibodies in Therapeutic Preparation of Human Intravenous Immunoglobulin (IVIG)
Cytokine Antibodies
Cytoskeletal Autoantibodies/Anti-actin Antibodies
Fibrillarin Autoantibodies
Fibronectin Autoantibodies
Interferon-inducible
Protein IFI 16 Autoantibodies
CARDIAC AUTOANTIBODIES
Autoantibodies in Atherosclerosis
Heat Shock Protein Autoantibodies
Myocardial Auto-antibodies and Their Clinical Significance
ENDOCRINE AUTOANTIBODIES
Glutamic Acid Decarboxylase Autoantibodies
Insulin Autoantibodies/Islet Cell Autoantibodies/Other Autoantibodies in IDDM
Antibodies to Adrenal, Gonadal Tissues and Steroidogenic
Enzymes
Thyroglobulin Autoantibodies/Thyroid Peroxidase Autoantibodies/Thyrotropin Receptor
GI AND LIVER AUTOANTIBODIES
Anti-Intestinal Goblet Cell Antibodies
Tumor Associated Autoantibodies
Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus
Infection
Anti-tissue Transglutaminase and Anti-endomyisial Antibodies
Anti-gliadin Antibodies
Reticulin Autoantibodies
Liver Cytosol
Antigen Type 1 Autoantibodies (LC-1), Liver Kidney Microsomal Autoantibodies (LKM), and Liver Microsomal Autoantibodies (LM)
Antimitochondrial
Antibodies
Parietal Cell and Intrinsic Factor Autoantibodies
Smooth Muscle Autoantibodies
HEMATOLOGIC AUTOANTIBODIES
Coagulation Factor Autoantibodies
Autoantibodies in Heparin-Induced Thrombocytopenia
Platelet Autoantibodies
Red Cell Autoantibodies
Lymphocytotoxic Autoantibodies
KIDNEY AUTOANTIBODIES
Anti-ATP Synthase – -Chain Autoantibodies
Glomerular Basement Membrane
Autoantibodies
Nephritic Factor Autoantibodies
NEUROLOGICAL SYSTEM AUTOANTIBODIES
Acetylcholine Receptor and Muscle
Specific Kinase Autoantibodies
Myositis Autoantibodies: Aminoacyl-tRNA Synthetase, Signal Recognition Particle, Mi-2, and PM-Scl Autoantibodies
Anti-MOG Antibodies
Antibodies to Hsp 70 in Inner Ear Disease
Autoantibodies in the Lambert-Eaton Myasthenic Syndrome (LEMS) and Amyotrophic
Lateral Sclerosis (ALS)
Ganglioside Autoantibodies
Myelin Associated Antibodies: Myelin-associated Glycoprotein Autoantibodies,
Myelin
Basic Protein Autoantibodies and Myelin Proteolipid Autoantibodies in Neurologic Diseases
Paraneoplastic Neurological Antibodies: 1.
Nuclear
Paraneoplastic Neurological Antibodies: 2. Purkinje Cell Cytoplasm
Paraneoplastic Neurological Antibodies: 3. Additional Reactivities
Retinal Autoantibodies
Autoantibodies in Epilepsy
RHEUMATIC DISEASE AUTOANTIBODIES
Anti-fodrin Antibodies
Antibodies
to Laminin
Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjogren s Syndrome
B2 VGlycoprotein I Autoantibodies
C1 Inhibitor Autoantibodies
Autoantibodies to C1q
Anti-Collagen Antibodies
Anti-cyclic citrullinated peptide Antibody
Anti-endothelial
Cell Autoantibodies
Lupus Anticoagulant Testing
Anti-cardiolipin Antibodies
Phospholipid Autoantibodies (Non Anti-cardiolipin)-Anti-Prothrombin
Antibodies
Rheumatoid Factors
SKIN DISEASE AUTOANTIBODIES
Autoantibodies to Mucocutaneous Antigens
UNIQUE CLINICAL
SITUATIONS
Autoimmunity and the Newer Biopharmaceuticals
Autoantibodies Against Tumor Suppressor Proteins
Detection of Autoantibodies
Using Protein Arrays
Autoantibodies and Pregnancy Loss
Anti Glycan Antibodies
FUTURE DIRECTIONS
| Bibliographic details |
Hardbound, 872 pages, publication date: NOV-2006
ISBN-13: 978-0-444-52763-9
ISBN-10: 0-444-52763-X
Imprint: ELSEVIER
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Last update: 30 Nov 2009
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