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TARGET VALIDATION IN DRUG DISCOVERY
Target Validation in Drug Discovery
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Edited By
Brian Metcalf, Chief Drug Discovery Officer, Incyte Corporation, Moraga, CA, U.S.A.
Susan Dillon, Senior Vice President, Discovery Research Centocor, Johnson & Johnson, Malvern, PA, U.S.A.

Description
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Audience
Professionals in biotechnology and pharmaceutical drug discovery and clinical development. Can also include students and academics in the related areas of study.

Contents
Section Contents I. Pharmaceutical Biotechnology for Target Validation II. Target Validation for Biopharmaceutical Drug Discovery III. Validating Targets of Small Molecule Approaches

Bibliographic details
Hardbound, 296 pages, publication date: SEP-2006
ISBN-13: 978-0-12-369393-8
ISBN-10: 0-12-369393-4
Imprint: ACADEMIC PRESS

Price and Ordering
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EUR 70.95
GBP 60
USD 94.95
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Last update: 5 Sep 2009
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