Mosby Physiology Monograph Series To order this title, and for more information, click here Fourth Edition
By Bruce Koeppen, MD, PhD, Professor of Medicine & Physiology, Dean Academic Affairs & Education, University of Connecticut Health Center, Farmington, CT Bruce Stanton, PhD, Professor of Physiology, Department of Physiology, Dartmouth Medical School, Hanover, NH
Description This volume in the Mosby Physiology Monograph Series explains the fundamentals of renal physiology in a clear and concise manner. It provides
you with a basic understanding of normal kidney function at the cellular and molecular level. Attractively illustrated with clear 2-color
diagrams, this volume also facilitates study with learning objectives, overview boxes, chapter summaries, and clinical cases with questions
and explained answers. Plus, online access via STUDENT CONSULT makes this an even more powerful learning resource.
Contents Introduction to the Kidney
1 Physiology of Body Fluids
OBJECTIVES PHYSICOCHEMICAL PROPERTIES OF ELECTROLYTE
SOLUTIONS Molarity and Equivalence Osmosis and Osmotic Pressure Osmolarity and Osmolality Tonicity Oncotic Pressure Specific
Gravity VOLUMES OF BODY FLUID COMPARTMENTS COMPOSITION OF BODY FLUID COMPARTMENTS FLUID EXCHANGE BETWEEN BODY FLUID COMPARTMENTS Capillary
Fluid Exchange Cellular Fluid Exchange SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY PROBLEMS
2 Structure
and Function of the Kidneys
OBJECTIVES STRUCTURE OF THE KIDNEYS Gross Anatomy Ultrastructure of the Nephron Ultrastructure
of the Renal Corpuscle Ultrastructure of the Juxtaglomerular Apparatus Innervation of the Kidneys SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY
PROBLEMS
3 Glomerular Filtration and Renal Blood Flow
OBJECTIVES RENAL CLEARANCE Glomerular
Filtration Rate GLOMERULAR FILTRATION Determinants of Ultrafiltrate Composition Dynamics of Ultrafiltration RENAL BLOOD FLOW REGULATION
OF RENAL BLOODS FLOW AND GLOMERULAR FILTRATION RATE Sympathetic Nerves Angiotensin II Prostaglandins Nitric Oxide Endothelin Bradykinin Adenosine Natriuretic
Peptides ATP Glucocorticoids Histamine Dopamine SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY PROBLEMS
4
Renal Transport Mechanisms: NaCl and Water Transport Along the Nephron
OBJECTIVES GENERAL PRINCIPLES OF MEMBRANE TRANSPORT GENERAL
PRINCIPLES OF TRANSEPITHELIAL SOLUTE AND WATER TRANSPORT NaCl, SOLUTE, AND WATER REABSORPTION ALONG THE NEPHRON Proximal Tubule Henle?s
Loop Distal Tubule and Collecting Duct REGULATION OF NaCL AND WATER REABSORPTION SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY
PROBLEMS
5 Regulation of Body Fluid Osmolality: Regulation of Water Balance
OBJECTIVES ANTIDIURETIC
HORMONE Osmotic Control of ADH Secretion Hemodynamic Control of ADH Secretion ADH Actions on the Kidneys THIRST RENAL
MECHANISMS FOR DILUTION AND CONCENTRATION OF THE URINE Medullary Interstitium Vasa Recta Function ASSESSMENT OF RENAL DILUTING
AND CONCENTRATING ABILITY SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY PROBLEMS
6 Regulation of Extracellular
Fluid Volume and NaCl Balance
OBJECTIVES CONCEPT OF EFFECTIVE CIRCULATING VOLUME VOLUME-SENSING SYSTEMS Vascular
Low-Pressure Volume Sensors Vascular High-Pressure Volume Sensors Hepatic Sensors Central Nervous System Na+ Sensors Volume
Sensor Signals Renal Sympathetic Nerves Renin-Angiotensin-Aldosterone System Natriuretic Peptides Antidiuretic Hormone CONTROL
OF RENAL NaCL EXCRETION DURING EUVOLEMIA Mechanisms for Maintaining the Delivery of Na+ to the Distal Tubule Constant Regulation
of Distal Tubule and Collecting Duct Na+ Reabsorption CONTROL OF Na+ EXCRETION WITH VOLUME EXPANSION CONTROL OF Na+ EXCRETION WITH
VOLUME CONTRACTION EDEMA Alterations in Starling Forces The Role of the Kidneys SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY
PROBLEMS
7 Regulation of Potassium Balance
OBJECTIVES OVERVIEW OF K+ HOMEOSTASIS REGULATION
OF PLASMA [K+] Epinephrine Insulin Aldosterone ALTERATIONS OF PLASMA [K+] Acid-Base Balance Plasma Osmolality Cell
Lysis Exercise K+ EXCRETION BY THE KIDNEYS CELLULAR MECHANISMS OF K+ SECRETION BY PRINCIPAL CELLS IN THE DISTAL TUBULE AND COLLECTING
DUCT REGULATION OF K+ SECRETION BY THE DISTAL TUBULE AND COLLECTING DUCT Plasma [K+] Aldosterone Antidiuretic Hormone FACTORS
THAT PERTURB K+ EXCRETION Flow of Tubular Fluid Acid-Base Balance Glucocorticoids SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY
PROBLEMS
8 Regulation of Acid-Base Balance
OBJECTIVES THE HCO3- BUFFER SYSTEM OVERVIEW OF ACID-BASE
BALANCE NET ACID EXCRETION BY THE KIDNEYS HCO3- REABSORPTION ALONG THE NEPHRON REGULATION OF H+ SECRETION Formation of New
HCO3- RESPONSE TO ACID-BASE DISORDERS Extracellular and Intracellular Buffers Respiratory Compensation Renal Compensation SIMPLE
ACID-BASE DISORDERS Metabolic Acidosis Metabolic Alkalosis Respiratory Acidosis Respiratory Alkalosis ANALYSIS OF ACID-BASE
DISORDERS SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY PROBLEMS
9 Regulation of Calcium and Phosphate Homeostasis
OBJECTIVES CALCIUM Overview
of Ca++ Homeostasis Ca++ Transport along the Nephron Regulation of Urinary Ca++ Excretion Calcium-Sensing Receptor PHOSPHATE Overview
of Pi Homeostasis Pi Transport along the Nephron Regulation of Urinary Pi Excretion INTEGRATIVE REVIEW OF PARATHYROID HORMONE,
CALCITRIOL, AND CALCITONIN ON Ca++ AND PI HOMEOSTASIS SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY PROBLEMS
10
Physiology of Diuretic Action
OBJECTIVES GENERAL PRINCIPLES OF DIURETIC ACTION Sites of Action of Diuretics Response
of Other Nephron Segments Adequate Delivery of Diuretics to Their Site of Action Volume of the Extracellular Fluid DIURETIC
BRAKING PHENOMENON MECHANISMS OF ACTION OF DIURETICS Osmotic Diuretics Carbonic Anhydrase Inhibitors Loop Diuretics Thiazide
Diuretics K+-Sparing Diuretics Aquaretics EFFECT OF DIURETICS ON THE EXCRETION OF WATER AND OTHER SOLUTES Solute-Free Water K+
Excretion HCO3- Excretion Ca++ and Pi Excretion SUMMARY KEY WORDS AND CONCEPTS SELF-STUDY PROBLEMS
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