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By David Stocum, Department of Biology, Indiana University-Purdue University Indianapolis, USA
Description The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the
reader with an overview of the basic and clinically-oriented research that is being done. Not only does the content cover a plethora
tissues and systems, it also includes information about the developmental plasticity of adult stem cells and the regeneration of appendages.
As part of its balanced presentation, Regenerative Biology and Medicine does address the biological/bioethical issues
and challanges involved in the new and exciting field of regenerative biology and medicine.
Audience
Researchers and students in biology, chemistry, and bioengineering; medical students; academic and clinical physicians; and research investigators
Contents Chapter 1: An Overview of Regenerative Biology and Medicine
Introduction
A Brief History of Regenerative Biology and Medicine
The
Biology of Regeneration
1. Regeneration Takes Place at all Levels of Biological Organization
2. Mechanisms of Regeneration at the Tissue
Level
3. Epimorphosis and Morphallaxis
4. Evolutionary Significance of Regeneration and Fibrosis
Strategies of Regenerative Medicine
1. Cell Transplantation
2. Bioartificial Tissues
3. Induction of Regeneration In Situ
Summary
References
Chapter 2: Repair
of Skin Wounds by Fibrosis
Introduction
Structure of Adult Mammalian Skin
The Effect of Wound Type and Extent on Dermal Repair
Phases
of Repair in Excisional Wounds
1. Hemostasis and Clot Formation
2. Inflammation
3. Structural Repair
4. The Role of Wound Contraction
in Dermal Repair
Molecular Comparison of Wounded vs. Unwounded Skin
Fetal Skin Heals Without Scarring
1. Cellular and ECM Differences
Between Fetal and Adult Wound Healing
2. Fetal Wounds have a Minimal Inflammatory Response
Summary
References
Chapter 3: Regeneration
of Epidermal Tissues
Introduction
Regeneration of Epidermis and Hair
1. Maintenance Regeneration
2. Injury-Induced Regeneration
of the IFE
Regeneration of Nails
Regeneration of Dental Tissues
Regeneration of the Lens
1. Structure of the Eye and Lens
2.
Cellular Events of Lens Regeneration in the Newt Eye
3. Transcription Factors Regulating Lens Regeneration
4. Signals Invlved in
Lens Regeneration
5. Mammals Have Some Capacity for Lens Regeneration
Regeneration of the Cornea
Summary
References
Chapter 4:
Regenerative Medicine of Skin, Hair and Dental Tissues
Introduction
Repair of Skin
1. Acceleration of Acute Wound Repair by Topically
Applied Agents
2. Acceleration of Repair in Chronic Wounds by Topically Applied Agents
3. Keratinocyte Transplants
4. Bioartificial
Skin Equivalents
5. Acellular Dermal Regeneration Templates
Use of Acellular Templates for Abdominal Wall Repair
Stimulation of Hair
Regeneration
Repair of Teeth and Peridontium
Corneal Regeneration
Summary
References
Chapter 5: Regeneration of Neural Tissues
Introduction
Axon Regeneration
1. Axons of Mammalian Spinal (Peripheral) Nerves
2. Axons of Mammalian Spinal Cord
3, Axons
of Amphibian Spinal Cord
4. Axons of Amphibian and Fish Optic Nerve
Maintenance Regeneration of Neurons in the Mammalian CNS
1.
Discovery of Neural Stem Cells
2. Regeneration of Olfactory Nerve and Bulb Neurons
3. Regeneration of Hippocampal Neurons
4.
Regeneration of Cortical Neurons
5. The CNS Neural Stem Cell Microniche
Injury-Induced CNS Regeneration
1. Avian and Mammalian
Auditory Sensory Neurons
2. Regeneration of Neurons in the Mammalian Brain
3. Regeneration of the Retina
4. Regeneration of the
Spinal Cord in Amputated Amphibian and Lizard Tails
Summary
References
Chapter 6: Regenerative Medicine of Neural Tissues
Introduction
Therapies for Injured Peripheral Nerve
Therapies for Injured Spinal Cord
1. Pharmaceutical Therapies
2. Regeneration Templates
3. Cell Transplant Therapies
4. Bioartificial Spinal Cord
5. Rehabilitation Programs and Synaptic Plasticity
6. Combinatorial
Approaches May Bring Better Success
Therapies for Neurodegenerative Diseases
1. Demyelinating Disorders
2. Parkinson!|s Disease
3. Huntington!|s Disease
4. Alzheimer!|s Disease
5. Amyotrophic Lateral Sclerosis
Summary
References
Chapter 7: Regeneration
of Digestive, Respiratory and Urogenital Tissues
Introduction
Intestinal Epithelium
1. Structure of the Intestinal Tract
2. Regeneration
of the Villous Epithelium
3. Regeneration of Transected Intestine
Liver
1. Structure and Function of the Mammalian Liver
2. Regeneration
by Compensatory Hyperplasia
3. Injury-Induced Regeneration via Stem Cells
4. Heterogeneity of Hepatocyte Size and Growth Potential
Pancreas
1. Structure and Function of the Pancreas
2. Regeneration of the Pancreas
3. Origin of Regenerated ?O-Cells
Alveolar
Epithelium of the Lung
1. Structure of the Respiratory System
2. Regeneration of Alveolar Epithelium
Kidney and Urinary System
1. Structure of the Kidney and Urinary System
2. Regeneration of Kidney Tubule Epithelium
Gonads
Prostate Tissue
Summary
References
Chapter 8: Regenerative Medicine of Digestive, Respiratory and Urinary Tissues
Introduction
Regenerative Therapies for the Liver
1. Hepatocyte Transplants
2. Extracorporeal Liver Assist Devices
Regenerative Therapies for the Pancreas
1. Cell Transplants
2. Suppression of Autoimmunity and Regeneration From Remaining ?O-Cells
3. Bioartificial Pancreas
4. Gene Therapy to Induce Islet
Neogenesis
Regenerative Therapies for the Esophagus and Intestine
1. Esophagus
2. Intestine
Regenerative Therapies for the Respiratory
System
1. Trachea
2. Lung
Regenerative Therapies for the Urinary System
1. Nephrons
2. Urinary Conduit Tissue
Summary
References
Chapter 9: Regeneration of Musculoskeletal Tissues
Introduction
Regeneration of Skeletal Muscle
1. Structure of Skeletal Muscle
2. Satellite Cells are the Source of Regenerated Muscle
3. Cellular and Molecular Events of Skeletal Muscle Regeneration
4. The
Activation and Proliferation of SCs is Regulated by a Variety of Signaling Molecules
5. Tension and Innervation are Required for Normal
Muscle Regeneration
Regeneration of Bone
1. Structure of Bone
2. Maintenance Regeneration of Bone
3. Injury-Induced Regeneration
of Bone
Repair of Articular Cartilage
Repair of Tendon and Ligament
1. Structure of Tendons and Ligaments
2. Repair of Tendons
and Ligaments
Summary
References
Chapter 10: Regenerative Medicine of Musculoskeletal Tissues
Introduction
Regenerative Therapies
for Muscle
1. Muscular Dystrophy
2. Bioartificial Muscle
Regenerative Therapies for Meniscus and Articular Cartilage
1. Meniscus
2. Articular Cartilage
Regenerative Therapies for Bone
1. Electromagnetic Field Stimulation
2. Ilizarov Distraction Technique
for Lengthening Bones
3. Induction of Bone Regeneration by Osteogenic Factors and Acellular Templates
4. Cell Transplants and Bioartificial
Bone
5. The Long Bones of Salamanders Can Regenerate When Removed
Regenerative Therapies for Tendon and Ligament
1. Tendon
2.
Ligament
Summary
References
Chapter 11: Regeneration of Hematopoietic and Cardiovascular Tissues
Introduction
Regeneration of Hematopoietic
Cells
1. Composition of Adult Blood
2. Hematopoietic Stem Cells of the Bone Marrow
3. Regulation of LT-HSC Activation and Proliferation
Regeneration of Blood Vessels
1. Development and Structure of the Vascular System
2. Blood Vessel Regeneration in Wounded Tissue
Regeneration of Cardiac Muscle
1. Structure of Cardiac Muscle
2. Mammalian Cardiac Muscle Does Not Regenerate, but Harbors Adult
Stem Cells
3. Amphibian and Zebrafish Cardiac Muscle Regenerates When Injured
Summary
References
Chapter 12: Regenerative Medicine
of Hematopoietic and Cardiovascular Tissues
Introduction
Therapies for Hematopoietic Disorders
1. Myeloablative Therapy
2. Non-Myeloablative
Therapy
3. The Future of Hematopoietic Transplants
4. Gene Therapy for Genetic Hematopoietic Diseases
Therapies for Blood Vessel
Regeneration
1. Stem Cell Transplants
2. Acellular Regeneration Templates
3. Bioartificial Blood Vessels
Therapies for Protection
and Regeneration of the Infarcted Myocardium
1. Transplants of Bone Marrow Cells
2. Satellite Cell Transplants
3. Cardiomyocyte
Transplants
4. Soluble Factors and Myocardial Regeneration
5. Bioartificial Cardiac Muscle
Summary
References
Chapter
13: Regenerative Medicine: Developmental Plasticity of Adult Stem Cells
Introduction
Assays to Test Developmental Plasticity
Experimental Results
1. Neural Stem Cells
2. Satellite Cells
3. Liver Oval Cells
4. Dental Pulp Cells
5. Unfractionated Bone
Marrow and HSCs
6. MSCs of the Bone Marrow and Related MSCs
Many Reports of Lineage Conversion are Due to Fusion With Host Cells
Adult Stem Cell Pluripotency: Fact or Fiction?
Might Organisms Contain ESC-Like Stem Cells in Their Tissues?
Effects of Aging on Number
and Developmental Status of Regeneration-Competent Cells
Summary
References
Chapter 14: Regeneration of Appendages
Introduction
Amphibian Limb Regeneration
1. Events of Limb Regeneration
2. Origin of the Blastema
3. Mechanism of Blastema Formation
4.
Epidermal and Neural Requirements for Survival and Proliferation of Blastema Cells
5. Developmental Plasticity of Blastema Cells in
Regenerating Amphibian Limbs
6. Spatial Organization of Tissue Patterns in the Regenerating Limb
7. Stimulation of Frog Limb Regeneration
8. Comparative Analysis of Gene Activity in Regeneration-Competent vs. Regeneration-Deficient Limbs
Regeneration of Amphibian Jaws
Appendage Regeneration in Mammals
1. Regeneration of Ear Tissue
2. Regeneration of Deer Antlers
3. Regeneration of Mouse and Human
Digit Tips
4. Stimulation of Digit and Limb Regeneration in Mice and Rats
Summary
References
Chapter 15: Research Issues in Regenerative
Medicine
Introduction
Biological Issues and Challenges.
1. Cell Sources for Transplantation and Bioartificial Tissue Construction
2. Expansion and Directed Differentiation of Regeneration-Competent Cells xiii
3. Challenges for Bioartificial Tissue Construction
4. The Challenge of Immunorejection
5. Challenges for the Chemical Induction of Regeneration
6. The Challenge of Curing Disease
Bioethical Issues and Challenges
1. The Derivation of Designer Human ESCs by SCNT
2. The Controversy Over Human ESC Research
3. Resolving an Unresolvable Dilemma
4. The Specter of Interspecies Grafting
Concluding Remarks
Summary
References
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