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By Reginald Gorczynski, MD, Professor, Department of Surgery and Immunology, University of Toronto Faculty of Medicine, Toronto, Ontario Jacqueline Stanley, PhD, Course Director and Professor of Immunology, Department of Microbiology and Immunology, St. George's University School of Medicine, St. George's, Grenada, West Indies
Description It's one thing to understand the basic science of immunology. It's another thing to know how that science applies to the realities of
patient care. This new resource uses skillfully presented clinical case studies to efficiently demonstrate the practical relevance of
immunology knowledge in diagnosing a wide range of challenging conditions. It offers as an ideal way to review the fundamental principles
of immunology ... and see them translated into real-world diagnosis and management!
Contents
IMMUNIZATION
Background
– Rationale for immunization – General principles of immunization – Broad
classes of vaccines – Role of adjuvants – Vaccine efficacy and safety – Vaccine strategies in development – Novel vaccine
applications
Cases
1. Deliberate natural immunization (Leishmania) 2. Immunization in the bioterrorist
era; small pox (or anthrax) 3. Immunization in the elderly (influenza) 4. Passive immunization: tetanus toxoid 5. Novel approaches
for HIV vaccines 6. Polio vaccines- Salk versus Sabin 7. Cancer vaccine
HYPERSENSITIVITY
Background
–
General principles – Gell and Coombs classifications – Sensitization and effector phases of Types I-IV hypersensitivity reactions
– General principles of tolerance
induction – Current evidence/hypothesis for loss of tolerance – Evidence supporting a role for genetics in autoimmune disorders –
Immunopathology associated with autoreactive antibodies – Immunopathology associated with T cell mediated damage
– General principles of primary and secondary immunodeficiency disorders – Dysfunctions
that lead to primary immunodeficiency disorders affecting (a) T cells and B cells combined, (b) T cells, (c) B cells, (d) Complement,
(e) phagocytes – Conditions that lead to secondary immunodeficiencies
– General Features – Surgical and ischemia/reperfusion
damage – Role of activated tissue macrophages and activated vascular endothelial cells – Adaptive immunity in graft rejection – Tissue matching – Non specific Immunosuppression – Specific Immunosuppression
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