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| TOXICOLOGY OF ORGANOPHOSPHATE & CARBAMATE COMPOUNDS
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Edited By
Ramesh Gupta, Murray State University, Breathitt Veterinary Center, Hopkinsville, KY, USA
Description
This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which
constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden.
Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic
agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity,
thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase
agents produce a variety of toxicological effects in target and nontarget organs.
In light of this complexicity, this multi-authored
book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters,
to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity,
and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical
warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases;
developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis.
Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides.
Audience
Toxicologists, Pharmacologists, Biologists/Neurochemists, Physicians, and Libraries
Contents
Foreword
Section-I Uses, Abuses & Epidemiology
1. Introduction
2. Classification and Uses of Organophosphates and Carbamates
3. Therapeutic
Uses of Cholinesterase Inhibitors in Neurodegenerative Diseases
4. Co-administration of Memantine with Acetylcholinesterase Inhibitors:
Preclinical and Clinical Evidence
5. Cholinesterase Inhibitors as Chemical Warfare Agents: Community Preparedness Guidelines
6. Organophosphates
and the Gulf War Syndrome
7. The Bhopal Accident and Methyl Isocyanate Toxicity
8. Global Epidemiology of Organophosphates and Carbamates
Poisonings
Section-II Pharmacokinetics & Metabolism
9. Physiologically Based Pharmacokinetic Modeling of Organophosphorus and Carbamate
Pesticides
10. Metabolism of Organophosphorus and Carbamate Pesticides
11. Interspecies Variation in Toxicity of Cholinesterase inhibitors
Section-III Esterases, Receptors, Mechanisms & Tolerance Development
12. Structure and Function of Cholinesterases
13. Cholinesterase
Pharmacogenetics
14. Methods for Measuring Cholinesterase Activities in Human Blood
15. Interactions of Organophosphorus and Carbamate
Compounds with Cholinesterases
16. Structure, Function and Regulation of Carboxylesterases
17. Non-Cholinesterase Mechanisms of Central
and Peripheral Neurotoxicity: Muscarinic Receptors and Other Targets
18. Paraoxonase (PON1) Polymorphisms and Toxicity of Organophosphates
19. Tolerance Development to Toxicity of Cholinesterase Inhibitors
Section-IV Organ Toxicity
20. CNS Effects and Neurotoxicity
21.
Developmental Neurotoxicity of Organophosphates: A Case Study of Chlorpyrifos
22. In Vitro Models for Testing Organophosphate-Induced
Neurotoxicity and Remediation
23. Electrophysiological Mechanisms in Neurotoxicity of Organophosphates and Carbamates
24. Behavioral
Toxicity of Cholinesterase Inhibitors
25. PNS Effects and Delayed Neuropathy
26. The Intermediate Syndrome in Organophosphate Poisoning
27. Cardiovascular Toxicity of Cholinesterase Inhibitors
28. Pulmonary Toxicity of Cholinesterase Inhibitors
29. Approaches in Defining
and Evaluating the Inhalation Pharmacology and Toxicology Hazards of Anticholinesterases
30. Dermal Absorption/Toxicity of Organophosphates
and Carbamates
31. Local and Systemic Ophthalmic Pharmacology and Toxicology of Organophosphate and Carbamate Anticholinesterases
32.
Reproductive Toxicity of Organophosphate and Carbamate Pesticides
33. Placental Toxicity of Organophosphate and Carbamate Pesticides
34. Endocrine Disruption by Organophosphate and Carbamate Pesticides
35. Organophosphates, Carbamates and the Immune System
Section-V
Non-Specific Toxic Effects
36. Oxidative Stress in Anticholinesterase Induced Excitotoxicity
37. DNA Damage, Gene Expression and Carcinogenesis
by Organophosphates and Carbamates
38. Temperature Regulation in Experimental Mammals and Humans Exposed to Organophosphate and Carbamate
Agents
39. Occupational Toxicology and Occupational Hygiene Aspects of Organophosphate and Carbamate Anticholinesterases with Particular
Reference to Pesticides
Section-VI Risk Assessment & Regulations
40. Public Health Impacts of Organophosphates and Carbamates
41. Cumulative
Effects of Organophosphorus or Carbamate Pesticides
42. Federal Regulations and Risk Assessment of Organophosphate and Carbamate Pesticides
43. Regulatory Considerations in Developmental Neurotoxicity of Organophosphorus and Carbamate Pesticides
44. WHO/FAO Guidelines for
Cholinesterase Inhibiting Pesticide Residues in Food
Section-VII Aquatic & Wildlife
45. Aquatic Toxicity of Carbamates and Organophosphates
46. Toxicity of Organophosphorus and Carbamate Insecticides Using Birds as Sentinels for Terrestrial Vertebrate Wildlife
Section-VIII
Analytical & Biomarkers
47. Analysis of Organophosphate and Carbamate Pesticides and Anticholinesterase Therapeutic Agents
48. Biomarkers
of Organophosphate Exposure
Section-IX Therapeutic Measures
49. Management of Organophosphorus Pesticide Poisoning
| Bibliographic details |
Hardbound, 768 pages, publication date: DEC-2005
ISBN-13: 978-0-12-088523-7
ISBN-10: 0-12-088523-9
Imprint: ACADEMIC PRESS
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| Price and Ordering |
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USD 175
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090/952
Last update: 5 Sep 2009
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