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| HANDBOOK OF BRAIN TUMOR CHEMOTHERAPY
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To order this title, and for more information, click here
Edited By
Herbert Newton, M.D., F.A.A.N., Director, Division of Neuro-Oncology, Department of Neurology, Co-Director, Dardinger Neuro-Oncology Center, Ohio State University Medical Center, Columbus, Ohio, USA
Description
Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in
the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development
of novel forms of chemotherapy, including ?targeted? agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art
of chemotherapy development and clinical treatment of patients with this devastating disease. Handbook of Brain Tumor Chemotherapy
offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing
what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic
agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy.
Audience
Neurosurgeons, neuro-oncologists, oncologists, neurologists, and oncological researchers with an interest in the development and application of chemotherapy to brain tumor patients.
Contents
I. Pharmacology and Clinical Applications.
1. Overview of Brain Tumor Epidemiology and Histopathology.
2. Clinical Pharmacology of Brain
Tumor Chemotherapy.
3. Chemotherapy and Anti-Epileptic Drug Interactions.
4. Brain Tumor Models for Cancer Therapy.
5. Microarray Analysis
and Proteomic Approaches to Drug Development.
6. Chemotherapy Resistance.
7. Clinical Trial Design and Implementation.
II. Molecular
Biology and Basic Science.
8. Molecular Genetics of Brain Tumors - An Overview
9. Regulation of the Cell Cycle and Interventional Developmental
Therapeutics.
10. Apoptosis Pathways and Chemotherapy.
11. Growth Factor Signaling Pathways and Receptor Tyrosine Kinase Inhibitors.
12. Ras Signaling Pathways and Farnesyl Transferase Inhibitors.
13. PI3-Kinase, PKB/Akt, mTOR, and Internal Signaling Pathways.
14. Tumor
Invasiveness and Anti-invasion Strategies.
15. Mechanisms of Angiogenesis in Brain Tumors and their Translation into Therapeutic Anti-tumor
Strategies.
16. Biology of the Blood-Brain and Blood-Brain Tumor Barriers.
III. Innovative Approaches to Chemotherapy Delivery.
17.
Intra-Arterial Chemotherapy.
18. Blood-Brain Barrier Disruption Chemotherapy.
19. Interstitial Chemotherapy and Polymer-Drug Delivery.
20. Intratumoral Administration and Convection-Enhanced Delivery.
21. Marrow Ablative Chemotherapy with Hematopoietic Stem Cell Rescue.
22. CSF Dissemination of Primary Brain Tumors.
23. Chemotherapy-Activating Gene Therapy.
IV. Chemotherapy of Specific Tumor Types.
24.
Chemotherapy of High-Grade Astrocytomas.
25. Chemotherapy of Low-Grade Astrocytomas.
26. Chemotherapy of Oligodendrogliomas.
27. Chemotherapy
of Oligoastrocytomas.
28. Chemotherapy of Primary Central Nervous System Lymphomas.
29. Chemotherapy of Medulloblastoma.
30. Chemotherapy
of Ependymoma.
31. Chemotherapy of Glioneuronal Tumors.
32. Chemotherapy of Pineal Parenchymal Tumors.
33. Current Therapeutic Management
Strategies for Primary Intracranial Germ Cell Tumors.
34. Chemotherapy of Menigiomas.
35. Chemotherapy for Brain Metasteses.
36. The
Role of Chemotherapy in Pediatric Gliomas.
| Bibliographic details |
Hardbound, 586 pages, publication date: DEC-2005
ISBN-13: 978-0-12-088410-0
ISBN-10: 0-12-088410-0
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
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USD 190
EUR 135.95
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095/945
Last update: 30 Nov 2009
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