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STRATEGIES AND TACTICS IN ORGANIC SYNTHESIS, 6
Strategies and Tactics in Organic Synthesis, 6
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Edited By
M. Harmata, University of Missouri, MO, USA

Included in series
Strategies and Tactics in Organic Synthesis,

Description
A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

Audience
Organic chemists; academic libraries, chemical and pharmaceutical companies

Contents


Chapter 1.
The Total Synthesis Of Luzopeptins (M.A. Ciufolini).

Chapter 2.
Synthesis of Geldanamycin Using Glycolate Aldol Reactions (M.B. Andrus et al.).

Chapter 3.
From Methylene Bridged Glycoluril Dimers To Cucurbit[N]Uril Analogs With Some Detours Along The Way (L. Isaacs, J. Lagona).

Chapter 4.
Application Of Silicon-Assisted Intramolecular Cross-Coupling In Total Synthesis Of (+)-Brasilenyne (S.E. Denmark, Shyh-Ming Yang).

Chapter 5.
Samarium(II) Promoted Ketyl Olefin Cyclizations Applied To The Total Syntheses Of (-)-Steganone And (+)-Isoschizandrin (G.A. Molander, K.M. George).

Chapter 6.
The Synthesis Of Polycavernoside A. An Example Of Conformationally Guided Macrolactonization (P.R. Blakemore, J.D. White).

Chapter 7.
First Total Synthesis Of Several Natural Products Based On Alkyne-Co2(Co)6 Complexes (Chisato Mukai).

Chapter 8.
Total Synthesis Of Myriaporones 1, 3, and 4 (R.E. Taylor et al.).

Chapter 9.
Adventures In Natural Product Synthesis: From Deep Sea Sponge To Pilot Plant. The Large Scale Total Synthesis Of The Marine Natural Product (+)-Discodermolide (S.J. Mickel).

Chapter 10.
Synthesis Of Aprepitant (T.D. Nelson).

Chapter 11.
Total Synthesis And Mechanism Of Action Studies On The Antitumor Alkaloid,(-)-Agelastatin A (K.J. Hale, M.M. Domostoj).

Chapter 12.
Design And Synthesis of Cooperative "Pinwheel" Fluorescent Sensors (J. Raker et al.).

Chapter 13.
Functionalization Of Pyridines And Thiazoles Via The Halogen-Dance Reaction, Application To The Total Synthesis Of Caerulomycin C And WS75624 B (T. Sammakia et al.).

Chapter 14.
Diastereoselective Intramolecular 4+3 Cycloaddition And An Enantioselective Total Synthesis Of (+)-Dactylol (P. Rashatasakhon, M. Harmata).

Bibliographic details
Hardbound, 500 pages, publication date: JUL-2005
ISBN-13: 978-0-12-450288-8
ISBN-10: 0-12-450288-1
Imprint: ACADEMIC PRESS

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Last update: 5 Sep 2009
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