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| MOLECULAR DIAGNOSTICS
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Edited By
George Patrinos, Erasmus University Medical Center, Rotterdam, Netherlands
Wilhelm Ansorge, European Molecular Biology Laboratory, Heidelberg, Germany
Description
Molecular Diagnostics covers current molecular biological techniques used to identify the underlying molecular defects
in inherited disease. Although an increasing number of laboratories, both academic and private are moving in that direction, there are
only a few books in the existing literature, and they deal only partly with diagnosis at the molecular level. Each chapter includes the
principle and a brief description of the technique, followed by exmples from the authors' own epertise. Contributors are well-known experts
in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage.
Audience
Postgraduate students, researchers, physicians and practicing scientists in molecular genetics; professionals from similar backgrounds
working in diagnostic laboratories in academia or industry; academic institutions and hospital libraries
Contents
Foreward
Preface
Molecular Diagnostics: Past, Present and Future
Allele-Specific Mutation Detection By PCR-ARMS And PCR-ASO
Competitive
Oligopriming
Oligonucleotide Ligation Assays for the Diagnosis of Inherited Diseases
Enzymatic and Chemical Cleavage Methods to Identify
Genetic Variation
Mutation Detection by Single Strand Conformation Polymorphism and Heteroduplex Analysis
Capillary Electrophoresis
Temperature
and Denaturing Gradient Gel Electrophoresis
Two-Dimensional Gene Scanning
Real-Time Polymerase Chain Reaction
Pyrosequencing
Molecular
Cytogenetics In Molecular Diagnostics
Detection of Genomic Duplications and Deletions
Analysis of Human Splicing Defects Using Hybrid
Minigenes
DNA Microarrays and Genetic Testing
Human Genome Microarray In Biomedical Applications
Use of High Throughput Mass Spectrographic
Methods To Identify Disease Processes
The Application of Proteomics To Disease Diagnostics
Identification of Genetically Modified Organisms
Pharmacogenetics and Pharmacogenomics: Impact on Drug Discovery and Development
Molecular Diagnostic Applications in Forensic Science
Molecular Diagnostics and Comparative Genomics in Clinical Microbiology
Preimplantation Genetic Diagnosis
Genetic Monitoring of Laboratory
Animals
The Use of Locus-Specific Databases in Molecular Diagnostics
Safety Analysis in Retroviral Gene Therapy: Identifying virus integration
sites in gene-modified cells
Automated DNA Hybridisation and Detection
The Use of Microelectronic-Based Techniques in Molecular Diagnostic
Assays
Miniaturization technologies for molecular diagnostics
Human Gene Patents and Genetic Testing
Genetic Counseling and Ethics in
Molecular Diagnostics
Genetic Testing and Psychology
Safety in Biomedical and Other Laboratories
Quality Management in the Laboratory
Glossary
Index
| Bibliographic details |
Hardbound, 488 pages, publication date: JUN-2005
ISBN-13: 978-0-12-546661-5
ISBN-10: 0-12-546661-7
Imprint: ACADEMIC PRESS
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Last update: 13 Jun 2009
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