Edited by
M. Bishr Omary, Palo Alto VA Medical Center, Stanford University, Palo Alto, California, U.S.A.
Pierre Coulombe, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.
Description
Intermediate filaments are a large family of proteins that are the cytoskeletal elements involved in a number of skin, liver, neuromuscular,
cardiac, eye and hair diseases. Intermediate filament genes are regulated in a tissue-and cell type-specific manner and their polymerized
protein products protects the cells and tissue they are part of against a variety of mechanical and nonmechanical stresses. This book
provides a comprehensive resource of methodology essentials, describing a variety of essential tools and assays for studying intermediate
filaments. The book provides user-friendly advice and protocols covering all aspects of intermediate filaments including protein isolation
and structure, protein and gene regulation, relationship to disease and apoptosis, and associated proteins. Both mammalian and non-mammalian
systems and animal models are covered, making this book a must-have for any investigator wishing to study IF genes or their protein products.
Included in series
Methods in Cell Biology
Audience:
Cell biologists, pharmacologists, and researchers in biological, biophysical or biomedical sciences.
