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A Choice on the Horizon
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Proceedings of the Final Meeting of the joint Rockefeller/Ernst Schering network on epididymal research (AMPPA: Applied Molecular Pharmacology
of Posttesticular Activity), Bellagio, Italy, October 2002
By
R.J Aitken, ARC Centre of Excellence in Biotechnology and Development, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia
B.T. Hinton, Department of Cell Biology, School of Medicine, Charlottesville, VA, USA
M.C. Orgebin-Crist, Center for Reproductive Biology Research, Vanderbilt University School of Medicine, Nashville, TN, USA
Description
In spite of the broad selection of contraceptive methods available 38% of all pregnancies are unintended worldwide and 22% end in an abortion.
These facts alone clearly indicate the strong need for broadening contraceptive choices.
The status of reproductive science, however,
has so far led only to pharmacological fertility control measures with high standards of safety, efficacy and convenience for females.
As far as men are concerned, there is still no effective reversible male contraceptive available. Nonetheless, one third of all contraceptive
methods used worldwide depend on male "cooperation".
With the new opportunities presented by molecular biology, there is now a realistic
chance that new effective reversible methods for male fertility control can be developed. However, much more basic research is needed
to reach this goal.
As a consequence the Rockefeller Foundation and the Ernst Schering Research Foundation decided to take up this challenge
and mounted a multi-year global collaborative effort, involving a network of top-level research institutions to intensify research on
the regulation of the male reproductive system with special emphasis on post-testicular activity, using new approaches in molecular pharmacology
(Application of Molecular Pharmacology of Posttesticular Activity - AMPPA - network).
Contents
Preface (U.-F. Habenicht). The AMPPA network as a successful model for public-private or private-private partnership (E. Diczfalusyet
al.). Regulation of epididymal principal cell functions by basal cells: role of transient receptor potential (Trp) proteins and cyclooxygenase-1
(COX-1) (G.P.H. Leung et al.). Epididymis-specific promoter-driven gene targeting: a new approach to control epididymal function? (K.
Suzuki et al.). Technologies for the study of epididymal-specific genes (R.J. Lye, B.T. Hinton). Antioxidant strategies in the epididymis
(P. Vernet et al.). Molecular diffusion in sperm plasma membranes during epididymal maturation (Y. Christova et al.). The importance
of redox regulated pathways in sperm cell biology (M.A. Baker, R.J. Aitken). Mouse models of infertility due to swollen spermatozoa T.G.
Cooper et al.). Post-meiotic gene products as targets for male contraception (R. Ivell, S. Danner, M. Fritsch). Male contraception -
a topic with many facets (R.J. Lye et al.). Immortalization by large T-antigen of the adult epididymal duct epithelium (C. Kirchhoff
et al.).
| Bibliographic details |
Hardbound, 108 pages, publication date: JUL-2004
ISBN-13: 978-0-444-51684-8
ISBN-10: 0-444-51684-0
Imprint: ELSEVIER
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| Price and Ordering |
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USD 265
EUR 225
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Last update: 5 Sep 2009
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