Description This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. Bioseparation
of Proteins is unique because it provides a background of the bioseparation processes, and it is the first book available to
emphasize the influence of the different bioseparation processes on protein inactivation.Bioseparation of Proteins
covers the extent, mechanisms of, and control of protein inactivation during these processes along with the subsequent and essential
validation of these processes. The book focuses on the avoidance of protein (biologicalproduct) inactivation at each step in a bioprocess.
It compares protein inactivation exhibited during the different bioseparation processes by different workers and provides a valuable
framework for workers in different areas interested in bioseparations.
Topics include separation and detection methods; estimates of
protein inactivation and an analysis of this problem for different separation processes; strategies for avoiding inactivation; the molecular
basis of surface activity and protein adsorption,process monitoring, and product validation techniques; and the economics of various
bioseparation processes and quality control procedures.
Audience
Chemical engineers and other scientists in biotechnology and pharmaceutical companies as well as graduate students and academics involved
in bioprocess research in general and bioseparation methods in particular.
Contents Introduction. Steps in Bioseparation Processes. High Resolution Fractionation Processes. Protein Inactivation during Bioseparation. Adsorption
Influence on Bioseparation and Inactivation. Process Monitoring and Validation. Applications and Economics of Bioseparation. Protein
Inactivation Avoidance and Refolding during Bioseparation. Subject Index.
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