 |
|
| PATHOBIOLOGY OF ALZHEIMER'S DISEASE
| |
| | |
|
|
To order this title, and for more information, click here
Peter Jenner, King's College, London, U.K.
Alison Goate, St. Louis University School of Medicine, Missouri, U.S.A.
Frank Ashall, St. Louis University School of Medicine, Missouri, U.S.A.
Description
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing
fields in the life sciences.
Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop'
sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research
areas.
The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead
to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these
advances, with chapters written by many of the leading researchers in the field.
With genetic studies as a backbone to this volume many
chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters
describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's
disease.
Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into
this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors.
Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research.
Contents
Alzheimer's Disease. An Historical and Scientific Overview. Biochemistry and Ultrastructure of Paired Helical Filaments. Tau and Its Significance
for Alzheimer's Disease. Mutations in the APP Gene in Alzheimer's Disease. Transcriptional Control of APP Expression. Post-Translational
(Non-Proteolytic) Modification of APP. Proteolytic Processing of APP. Neurotoxicity of B-Amyloid and APP. Biological Functions of APP.
Animal Models of Alzheimer's Disease. Relation of Plaques and Tangles to Alzheimer's Disease Phenotype. Apolipoprotein E and Alzheimer's
Disease. Subject Index.
| Bibliographic details |
Hardbound, 256 pages, publication date: OCT-1995
ISBN-13: 978-0-12-286965-5
ISBN-10: 0-12-286965-6
Imprint: ACADEMIC PRESS
|
| Price and Ordering |
Price:
GBP 111.99
EUR 131.95
USD 185
|  |
Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). USD prices apply to the Americas and Asia Pacific. EUR prices apply in Europe and the Middle East. GBP prices apply to the UK and all other countries.
|
See also information about conditions of sale & ordering procedures, and links to our regional sales offices.
|
095/945
Last update: 7 Sep 2009
|
|
| |
| | |
|
|
| |
Home | Elsevier Sites | Privacy Policy | Terms and Conditions | Feedback | Site Map | A Reed Elsevier Company