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| IMMUNOPHARMACOLOGY OF JOINTS AND CONNECTIVE TISSUES
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To order this title, and for more information, click here
Clive Page, King's College London, U.K.
M. Davies, Strangeways Research Laboratories, Cambridge, U.K.
John Dingle, Strangeways Research Laboratories, Cambridge, U.K.
Included in series
Handbook of Immunopharmacology,
Description
The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid
athritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an
enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic
applications for their preventions and treatment. Though a plethora of immunological studies have been published in recent years, little
has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence
of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for many pharmacologists interested
in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source
through the commissioning of a comprehensive collection of volumes on all aspects immunopharmacology. Editors have been sought after
for each volume who are not only active in their respective areas of expertise, but who also have distinctly pharmacological bias to
their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each
of the major cell types and classes of inflammatory responses that can affect them ("Systems"). The third covers different classes of
diseases as well as those under development ("Drugs").
Contents
Contributors.
Series Preface.
Preface.
Introduction.
The Background to Autoimmunity, W.M. Williams, M.R. Ehrenstein, and D.A. Isenberg.
Immunological Tolerance and its Implications for Autoimmunity, N.A. Mitchison.
Peptide Blockade and Antigen-specific Modulation
of Autoimmune Disease, D.C. Wraith.
Monoclonal Antibody Therapy of Experimental Arthritis - Comparison with Cyclosparin A for
Elucidating Cellular and Molecular Disease Mechanisms, M.E.J. Billingham.
Anti-CD4 and Other Antibodies to Cell Surface Antigens
for Therapy, F. Emmrich, H. Schulze-Koops, and G. Burmester.
Are Imbalances in Cytokine Function of Importance in the Pathogenesis
of Rheumatoid Arthritis?, M. Feldmann, F.M. Brennan, E.R. Abney, A. Hales, Y. Chernajovsky, P. Katsikis, A. Corcoran, C. Haworth,
A. Cope, D. Gibbons, C.Q. Chu, M. Field, B. Deleuran, R.O. Williams, and R.N. Maini.
Naturally Occuring Inhibitors of Cytokines, W.P. Arend and J.-M. Dayer.
Soluble Immunopeptides in Inflammatory Arthritis, J.A. Symons and G.W. Duff.
Inflammatory
Reactions in Arthritis, H.-G. Fassbender.
Connective Tissue Destruction in Rheumatoid Arthritis: Therapeutic Potential of Selective
Metalloproteinase Inhibitors, B. Henderson and S. Blake.
Lysosomal Cysteine Endopeptidases in the Degradation of Cartilage and
Bone, D.J. Buttle.
Glossary.
Key to Illustrations.
Index.
| Bibliographic details |
Hardbound, 288 pages, publication date: JAN-1994
ISBN-13: 978-0-12-206345-9
ISBN-10: 0-12-206345-7
Imprint: ACADEMIC PRESS
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Last update: 4 Sep 2009
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