Description Volume 70 begins with two "Foundations in Cancer Research" articles, a staple of the Advances in Cancer Research series.
The first article by Michael Stoker presents a review of some of the early advances made by cancer cell biology researchers. The second
article by Emmanuel Farber describes the methods by which researchers delineate the phenotype of cells and ways to alter these phenotypes
to prevent or delay carcinomas. Chidambaram and Dean illustrate the tumors and associated malformations of nevoid basal cell carcinoma.
Koli and Keski-Oja review the effects of how transforming growth factor-b regulates cell proliferation, differentiation, and morphogenesis
and its regulation by the steroid hormone superfamily. Jean-Marc Lemaitre and colleagues discuss the involvement of protooncogenes in
the control of the cell cycle and embryonic development with specific attention paid to c-Myc expression and c-Myc function. A review
of the various studies involving tumor-infiltrating lymphocytes and their possible role in cancer prevention is presented by Steven Rosenberg
and co-workers. Finally, Bruce Ponder and Darrin Smith review the genetic and biological aspects of multiple endocrine neoplasia type-2
syndromes and the phenotypes associated with ret mutations.
Audience
Researchers and students in basic and clinical science of cancer biology and oncology, plus related areas in genetics, immunology, virology, cell biology, and molecular biology.
Contents
Foundations in Cancer Research: M. Stoker,
Fundamentals of Cancer Cell Biology:
Introduction.
Antecedents.
Autobiographical Note.
Foundations of Tissue Culture.
Foundations of Cell Culture.
Clones.
The Immortals: Stable Cell Lines.
The Mortals: Cell Strains.
Food for Cells in Culture.
Growth Factors.
Short-Range Cell Interactions.
Junctional Communication.
Cell and
Substrate Adhesion.
The Tumor Viruses.
Cell Fusion.
Conclusion.
References.E. Farber,
The Step-by-Step Development
of Epithelial Cancer: From Phenotype to Genotype:
Cancer Development as Basic to Cancer Research.
Patterns of Development of
Epithelial Cancers.
A Working Hypothesis.
The Phenotypes.
The Genotypes.
The Challenge.
References.A. Chidambaram and M. Dean,
Genetics of the Nevoid Basal Cell Carcinoma Syndrome:
Introduction.
Clinicopathological Features of NBCCS.
Genetics
of NBCCS.
Strategies for Isolation of Candidate Genes.
Discussion.
References.K. Koli and J. Keski-Oja,
Transforming
Growth Factor-( System and Its Regulation by Members of the Steroid-Thyroid Hormone Superfamily:
Introduction.
Transforming
Growth Factor-(. Dual Effects of TGF-(on Cell Proliferation.
Regulation of Cell Differentiation by TGF-(. TGF-(in the Regulation of the
Immune System.
The Steroid-Thyroid Hormone Superfamily.
Steroid Hormone Regulation of TGF-( Isoform Expression.
Regulation of Plasminogen
Activation by Steroids.
Summary.
References.J.-M. Lemaitre, R.S. Buckle, and M. Mechali,
c-Mycin the Control
of Cell Proliferation and Embryonic Development:
Introduction.
The c-myc Gene.
Structural and Functional Features of
the c-Myc Protein.c-Myc as a Transcription Factor.c-Myc and Cell Proliferation.c-Myc in Embryonic
Development.c-Myc and Differentiation.c-Myc and Apoptosis.
References.S.A. Rosenberg, Y. Kawakami, P.F. Robbins,
and R.-F. Wang,
Identification of the Genes Encoding Cancer Antigens: Implications for Cancer Immunotherapy .
Introduction.
Methodology.
Human Melanoma Antigens Recognized by T Cells.
Cancer Therapies Based on the Molecular Identification of Cancer Antigens.
References.B.A.J. Ponder and D. Smith,
The MEN II Syndromes and the Role of the ret Proto-oncogene: .
Introduction.
The MEN II Syndromes.
The ret Proto-oncogene.
Development of the Tissues Involved in MEN II, and Patterns of ret
Expression.
Speculations on How Different ret Mutations Result in the Associated Phenotypes and in Tumor Formation.
Other Events
in Tumor Progression.
Animal Models of MEN II.
Clinical Implications of the Identification of ret Mutations in MEN II.
Future
Prospects.
References.
Subject Index.
Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). USD prices apply to the Americas and Asia Pacific. EUR prices apply in Europe and the Middle East. GBP prices apply to the UK and all other countries.
Home | Elsevier Sites | Privacy Policy | Terms and Conditions | Feedback | Site Map | A Reed Elsevier Company