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| CONJUGATION-DEPENDENT CARCINOGENICITY AND TOXICITY OF FOREIGN COMPOUNDS, 27
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J. August, John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.
M. Anders, University of Rochester; Department of Pharmacology, New York, U.S.A.
Ferid Murad, University of Texas Medical School, Houston, U.S.A.
Wolfgang Dekant, Universitat Wurzburg
Included in series
Advances in Pharmacology,
Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on
the molecular basis of drug action, both applied and experimental.
Conjugation reactions have long been associated with the detoxification
of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.
This
special volume of Advances in Pharmacology features a two-color dust jacket.
Audience
Researchers in biochemistry, bioorganic chemistry, medicinal and pharmaceutical chemistry, pharmacology, and toxicology.
Contents
J.A. Miller and Y.-J. Surh, Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds.
Glutathione-Dependent
Toxicity:
C. Andersson, E. Mosialou, R. Weinander, and R. Morgenstern, Enzymology of Microsomal Glutathione S-Transferase.
B. Ketterer and L.G. Christodoulides, Enzymology of Cytosolic Glutathione S-Transferases.A.J.L. Cooper, Enzymology
of Cysteine S-Conjugate b-Lyases.W. Dekant, S. Vamvakas,and M.W. Anders, Formation and Fate of Nephrotoxic and Cytotoxic
Glutathione S-Conjugates: Cysteine Conjugate b-Lyase Pathway.T.A. Baille and K. Kassahun, Reversibility in Glutathione-Conjugate
Formation.T.J. Monks and S.S. Lau, Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites.F.P.
Guengerich, Metabolism and Genotoxicity of Dihaloalkanes.R. Munday, Bioactivation of Thiols by One-Electron Oxidation.
N. Ballatori, Glutathione Mercaptides as Transport Forms of Metals.
Sulfate Conjugate-Dependent Toxicity:
C.N.
Falany and T.W. Wilborn, Biochemistry of Cytosolic Sulfotransferases Involved in Bioactivation.C.J. Michejda and M.B.K. Koepke,
Carcinogen Activation by Sulfate Conjugate Formation.
Glucuronide Conjugate-Dependent Toxicity:
K.W. Bock UDP-Glucuronsyltransferases
and Their Role in Metabolism and Disposition of Carcinogens.P. Zia-Amirhosseini, H. Spahn-Langguth, and L.Z. Benet, Bioactivation
of Glucuronide-Conjugate Formation.
Bioactivation and Bioconversion:
P.E. Hanna, N-Acetyltransferases, O-Acetyltransferases, and N,O-Acetyltransferases: Enzymology and Bioactivation.M.W. Anders and W. Dekant,
Aminoacylases.J.L. Hoffman, Bioactivation by S-Adenosylation, S-Methylation, or N-Methylation.S. Vamvakas and M.W. Anders,
Bioconversion of Prodrugs by Conjugate-Processing Enzymes.
Subject Index.
| Bibliographic details |
Hardbound, 519 pages, publication date: MAY-1994
ISBN-13: 978-0-12-032927-4
ISBN-10: 0-12-032927-1
Imprint: ACADEMIC PRESS
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