Description This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these
critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific
interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a
diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series.
Volume 4 describes work on the modification
of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective
binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein
interactions using DNase I footprinting methodology.
Features include: • Expert contributors from the Biomedical world•
Emerging areas of drug design and therapeutic applications• Nucleic acid-protein interactions• Color graphics of molecular
modeling analyses• New and emerging methodologies
Contents 1. Preferential damage to defined regions of genomic DNA by AT-specific anticancer drugs (J.M. Woynarowski).
2. DNA-alkylating events
associated nitrogen mustard based anticancer drugs and the metabolic byproduct acrolein (M.E. Colvin, J.N. Quong).
3. Molecular basis
for recognition and binding of specific DNA sequences by calicheamicin and duocarmycin (G. Bifulco, et al.).
4. Enediyne antibiotic
neocarzinostatin as a radical-bsed probe of bulged structures in nucleic acids (Zhen Xi, I.H. Goldberg).
5. Sequence-specific DNA binding
by short peptides (T. Morii, K. Makino).
6. Equilibrium and kinetic quantitative DNAse I footprinting (G.M. Dhavan, A.K.M.M. Mollah,
M. Brenowitz).
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