 |
|
| UNIVERSES IN DELICATE BALANCE: CHEMOKINES AND THE NERVOUS SYSTEM
| |
| | |
|
|
To order this title, and for more information, click here
Edited By
R.M. Ransohoff, Cleveland Clinic Foundation, The Lerner Research Institute, Mellen Center for MS Treatment and Research, 9500 Euclid Avenue, Cleveland, OH 44195, USA
K. Suzuki, University of North Carolina, Pathology & Lab Medicine, 410 Brinkhous Bullitt Bldg, Chapel Hill, NC 27599, USA
A.E.I. Proudfoot, Serono Pharmaceutical Research Institute, 1228 Plan les Ouates, Switzerland
W.F. Hickey, Dartmouth-Hitchcock Medical Center, Department of Pathology, One Medical Center Drive, Lebanon, NH 03756-0001, USA
J.K. Harrison, University of Florida, College of Medicine, Box 100267, Gainesville, FL 32610-0267, USA
Description
It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their
intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition
by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are
predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized
as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of
inflammation, immunity and hematopoietic development.
Only recently have the two fields, neurobiology and immunology, displayed mutual
interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12)
and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12
and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow
and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction
of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane
ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As
may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue.
This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced
'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described,
as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions
are separately treated in varying contexts.
The field of 'neurobiology of chemokines' has not lain fallow during the last ten years.
During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations
of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium
and angiogenesis.
Understanding human disease is the goal of much of this research. New discoveries are being made and reported at
a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this
developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines
and discussing the relations of chemokine science to animal models and human disease.
Contents
Preface.
1. The nervous system (K. Suzuki).
1.1 Cellular elements, tissue organization, organogenesis (J. Dupree).
1.2 Cellular reactions
to insult (K. Suzuki).
1.3 Patterns of tissue pathology in neurological diseases (K. Suzuki).
2. The chemokine system(A.E.I. Proudfoot).
2.1 The biology of chemokines (B. Rollins).
2.2 Chemokines (A.E.I. Proudfoot, J.P. Shaw, C.A. Power, T.N.C. Wells).
2.3 Chemokine
receptors (D. Slattery, N. Gerard, C. Gerard).
2.4 Chemokine receptor signal transduction (K. Bacon).
2.5 Development and function
of the hemato-lymphopoiteic system (G.N. Schwartz, J.M. Farber).
2.6 CXC chemokines in angiogenesis (R.M. Strieter, J.A. Belperiio,
D.A. Arenberg, M.I. Smith, M.D. Burdiek, M.P. Keane).
3. Chemokines and neural inflammation in model systems (W.F. Hickey).
3.1 Expression,
functions and interactions of chemokines in CNS trauma (V.W. Yong).
3.2 Animal models of multiple sclerosis (W.J. Karpus).
3.3 Chemokines
and neonatal excitotoxic brain injury (J.M. Galasso, F. Silverstein).
3.4 Stroke: chemokine-induced infiltration of immune cells (H.W.G.M.
Boddeke).
3.5 Chemokine responses in virus-induced neurologic disease: balancing host defence and neuropathology (T.E. Lane, M.J. Buchmeier).
3.6 Cell recruitment in the axotomized facial nucleus: role of cytokines, chemokines and cell adhesion molecules (G. Raivich).
3.7
Chemokines and neural inflammation in experimental brain abscesses (T. Kielian, W.F. Hickey).
3.8 Insights from transgenic and knockout
mice (I.L. Campbell, V.C. Asensio).
4. Chemokines effects on other CNS processes and resident cells (J.K. Harrison).
4.1 Constitutive
roles for SDF-1/CXCR4 and fractalkine/CX3CR1 in the CNS (J.K. Harrison).
4.2 The role of the chemokine GRO-1 in the development of vertebrate
CNS glial cells (R.H. Miller, S. Robinson).
4.3 Chemokine interactions with astrocytes (M.E. Dorf, F.R. Fischer, M.A. Berman, Y. Luo).
4.4 Why do neurons express chemokine receptors? (R.J. Miller, S.B. Oh).
4.5 Microglial chemokines and chemokine receptors (K. Biber).
4.6 Chemokines and chemokine receptors along the brain microvasculature (A.V. Andjelkovic, J.S. Pachter).
5. Chemokines and neurological
diseases (R. Ransohoff).
5.1 Chemokines and chemokine receptors in multiple sclerosis: a few answers and many more questions (R. Ransohoff,
C. Trebst).
5.2 Chemokines in the central nervous system and Alzheimer's Disease (M. Xia, B.T. Hyman).
5.3 HIV-1 associated dementia
(D. Gabuzda, J. Wang, P.R. Gorry).
5.4 Infections: meningitis and encephalitis (K.S. Spanaus, A. Fontana).
5.5 Chemokines in the inflamed
peripheral nervous system (B.C. Kieseier, H.-P. Hartung).
| Bibliographic details |
Hardbound, 404 pages, publication date: APR-2002
ISBN-13: 978-0-444-51002-0
ISBN-10: 0-444-51002-8
Imprint: ELSEVIER
|
| Price and Ordering |
Price:
USD 240
GBP 144.99
EUR 171.95
|  |
Books and book related electronic products are priced in US dollars (USD), euro (EUR), and Great Britain Pounds (GBP). USD prices apply to the Americas and Asia Pacific. EUR prices apply in Europe and the Middle East. GBP prices apply to the UK and all other countries.
|
See also information about conditions of sale & ordering procedures, and links to our regional sales offices.
|
092/941
Last update: 4 Sep 2009
|
|
| |
| | |
|
|
| |
Home | Elsevier Sites | Privacy Policy | Terms and Conditions | Feedback | Site Map | A Reed Elsevier Company